ArticleHorticulture research2023
Multiple-model GWAS identifies optimal allelic combinations of quantitative trait loci for malic acid in tomato.
Article in Horticulture research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Integrating genome-wide association study and transcriptomic profiling identifies candidate genes underlying soluble solids content in melon (Horticulture research · 2026Article
- New biologically relevant resistance to bacterial wilt in heat-stressed tomato revealed by two-reference Genome Wide Association.PLoS genetics · 2026Article
- Identifying candidate genes for trichome traits in grapevine through a genome-wide association study.BMC genomics · 2026Article
- Molecular orchestration of malate and citrate metabolism: regulatory networks governing organic acid dynamics and fruit quality attributes.Horticulture research · 2026Article
- Identification of candidate genes for malic acid content in tomato fruits and development of associated SNP markers.Frontiers in plant science · 2026Article
- Regulatory Mechanisms of Total Soluble Solids in Tomato: From QTL Mapping to Gene Editing.Foods (Basel, Switzerland) · 2025Review
- Malate metabolism in horticultural crops: mechanistic insights and agricultural practices for quality improvement.Molecular horticulture · 2025Review
- Structural Insights Into the Role of RxLR Effectors in the Arms Race Between Oomycetes and Plants.Molecular plant pathology · 2025Review
- Rice QTL hotspots related with seed grain size, shape, weight, and color based on genome wide association study and linkage mapping.Scientific reports · 2025Article
- Genome-wide association study of salicylic acid provides genetic insights for tea plant selective breeding.Horticulture research · 2025Article
- Molecular breeding of tomato: Advances and challenges.Journal of integrative plant biology · 2025Review
- Genome-wide association studies in a diverse strawberry collection unveil loci controlling agronomic and fruit quality traits.The plant genome · 2024Article
- The art of tartness: the genetics of organic acid content in fresh fruits.Horticulture research · 2024Article
- Multi-omic applications for understanding and enhancing tropical fruit flavour.Plant molecular biology · 2024Review
- Genome-wide variants and optimal allelic combinations for citric acid in tomato.Horticulture research · 2024Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Malic acid (MA) is an important flavor acid in fruits and acts as a mediator in a series of metabolic pathways. It is important to understand the factors affecting MA metabolism for fruit flavor improvement and to understand MA-mediated biological processes. However, the metabolic accumulation of MA is controlled by complex heredity and environmental factors, making it difficult to predict and regulate the metabolism of MA. In this study, we carried out a genome-wide association study (GWAS) on MA using eight milestone models with two-environment repeats. A series of associated SNP variations were identified from the GWAS, and 15 high-confidence annotated genes were further predicted based on linkage disequilibrium and lead SNPs. The transcriptome data of candidate genes were explored within different tomato organs as well as various fruit tissues, and suggested specific expression patterns in fruit pericarp. Based on the genetic parameters of population differentiation and SNP distribution, tomato MA content has been more influenced by domestication sweeps and less affected by improvement sweeps in the long-term history of tomato breeding. In addition, genotype × environment interaction might contribute to the difference in domestication phenotypic data under different environments. This study provides new genetic insights into how tomato changed its MA content during breeding and makes available function-based markers for breeding by marker-assisted selection.
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