ArticleFrontiers in genetics2023
Identification of copy number variants contributing to hallux valgus.
Article in Frontiers in genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Factors Related to the Etiology of Hallux Abducto Valgus: A Systematic Review.Journal of functional morphology and kinesiology · 2026Review
- Assessment of tibialis anterior tendon insertion variations in relation to hallux valgus utilizing magnetic resonance imaging.Journal of orthopaedic surgery and research · 2024Article
- Effects of 4 weeks of foot exercise on subjective outcome and foot plantar pressure in elite adolescent dancers with hallux valgus: a pilot study.BMC sports science, medicine & rehabilitation · 2024Article
- Hallux valgus in preprofessional adolescent dancesport athletes: Prevalence and associated training factors.Journal of foot and ankle research · 2024Article
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hallux valgus is a common form of foot deformity, and genetic factors contribute substantially to the pathogenesis of hallux valgus deformity. We conducted a genetic study on the structural variants underlying familial hallux valgus using whole exome sequencing approach. Twenty individuals from five hallux valgus families and two sporadic cases were included in this study. A total of 372 copy number variations were found and passed quality control filtering. Among them, 43 were only present in cases but not in controls or healthy individuals in the database of genomic variants. The genes covered by these copy number variations were enriched in gene sets related to immune signaling pathway, and cytochrome P450 metabolism. The hereditary CNVs demonstrate a dominant inheritance pattern. Two candidate pathogenic CNVs were further validated by quantitative-PCR. This study suggests that hallux valgus is a degenerative joint disease involving the dysregulation of immune and metabolism signaling pathways.
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