ReviewFrontiers in neural circuits2023
Inhibitory circuits in fear memory and fear-related disorders.
Review in Frontiers in neural circuits, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Aperiodic and oscillatory activity of the human brain during induced emotional states.medRxiv : the preprint server for health sciences · 2026Article
- The circuitry regulation of associative learning: dissociated and integrated function of the perirhinal cortex and hippocampus.Frontiers in neural circuits · 2026Review
- Amygdala-hippocampus connectivity and childhood depressive symptoms: subnuclei insights and self-concept roles.Translational psychiatry · 2025Article
- Endocannabinoids inhibit contextual fear memory generalization via hippocampal GABAergic synaptic transmission.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Alprazolam induces anterograde amnesia for contextual fear memory and alters dorsoventral hippocampal neuronal ensembles in female mice.Scientific reports · 2025Article
- δ-Containing GABAJournal of neurophysiology · 2025Article
- Distinct ventral hippocampal inhibitory microcircuits regulating anxiety and fear behaviors.Nature communications · 2024Article
- GABAergic/Glycinergic and Glutamatergic Neurons Mediate Distinct Neurodevelopmental Phenotypes ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Synaptic and dendritic architecture of different types of hippocampal somatostatin interneurons.PLoS biology · 2024Article
- Synaptic configuration and reconfiguration in the neocortex are spatiotemporally selective.Anatomical science international · 2024Review
- Nucleus accumbens core single cell ensembles bidirectionally respond to experienced versus observed aversive events.Scientific reports · 2023Article
- Structural Organization of Perisomatic Inhibition in the Mouse Medial Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Trait self-compassion enhances activation in the medial prefrontal cortex during fear extinction: An fNIRS study.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Fear learning and memory rely on dynamic interactions between the excitatory and inhibitory neuronal populations that make up the prefrontal cortical, amygdala, and hippocampal circuits. Whereas inhibition of excitatory principal cells (PCs) by GABAergic neurons restrains their excitation, inhibition of GABAergic neurons promotes the excitation of PCs through a process called disinhibition. Specifically, GABAergic interneurons that express parvalbumin (PV+) and somatostatin (SOM+) provide inhibition to different subcellular domains of PCs, whereas those that express the vasoactive intestinal polypeptide (VIP+) facilitate disinhibition of PCs by inhibiting PV+ and SOM+ interneurons. Importantly, although the main connectivity motifs and the underlying network functions of PV+, SOM+, and VIP+ interneurons are replicated across cortical and limbic areas, these inhibitory populations play region-specific roles in fear learning and memory. Here, we provide an overview of the fear processing in the amygdala, hippocampus, and prefrontal cortex based on the evidence obtained in human and animal studies. Moreover, focusing on recent findings obtained using genetically defined imaging and intervention strategies, we discuss the population-specific functions of PV+, SOM+, and VIP+ interneurons in fear circuits. Last, we review current insights that integrate the region-specific inhibitory and disinhibitory network patterns into fear memory acquisition and fear-related disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.