Evidence map›Paper›PMID 37035485›Full record

ArticleJournal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology2022

Photosensitized co-generation of nitric oxide and singlet oxygen Enhanced toxicity against ovarian cancer cells.

Pedro Sanchez-Cruz, Katerina Vazquez, Eunice L Lozada, Fatima Valiyeva, Rohit Sharma, Pablo E Vivas, Antonio E Alegria

Open access · greenAbstract read
In one paragraph

Article in Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 66% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Pedro Sanchez-CruzDepartment of Chemistry, University of Puerto Rico, Humacao, PR 00791.
Katerina VazquezDepartment of Biochemistry, UPR Medical Sciences Campus, San Juan, PR 00936.
Eunice L LozadaComprehensive Cancer Center, UPR Medical Sciences Campus, San Juan, PR 00936.
Fatima ValiyevaComprehensive Cancer Center, UPR Medical Sciences Campus, San Juan, PR 00936.
Rohit SharmaComprehensive Cancer Center, UPR Medical Sciences Campus, San Juan, PR 00936.
Pablo E VivasDepartment of Biochemistry, UPR Medical Sciences Campus, San Juan, PR 00936.
Antonio E AlegriaDepartment of Chemistry, University of Puerto Rico, Humacao, PR 00791.
University of Puerto Rico, Medical Sciences Campus · PRUniversity of Puerto Rico at Humacao · PR

Funding

Upstream Regulation and Downstream effectors of c-MYC in Ovarian CancerU54MD007600 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI Abiel Roche-Lima · 2017 to 2026
$35.8M
TRANSLATIONAL PROTEOMICS CENTERG12MD007600 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI FERNANDEZ-REPOLLET, EMMA · 2012 to 2016
$11.0M
NIMHD NIH HHS G12 MD007600NIMHD NIH HHS U54 MD007600
6 · The paper itself

Abstract

Near micromolar concentrations of nitric oxide (NO) induce tumor cells death. However, an appropriate NO load has to be delivered selectively to the tumor site in order to avoid NO loss and secondary NO-induced effects. The encapsulation of millimolar concentrations of a NO source and an appropriate trigger of NO release within phospatidylcholine-based liposomes should provide an efficient tool for the selective release of the needed NO payload. In this work we report the photosensitized generation of singlet oxygen and NO from folate-targeted PEGylated liposomes, containing AlPcS4 as the sensitizer and

Identifiers

PMID37035485
PMCPMC10081534
OpenAlexW4224137959

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.