Evidence map›Paper›PMID 37035447›Full record

ArticleStem cells international2023

BMSC-Derived Exosomes Alleviate Sepsis-Associated Acute Respiratory Distress Syndrome by Activating the Nrf2 Pathway to Reverse Mitochondrial Dysfunction.

Zhenzhen Li, Beijie Zheng, Chenchen Liu, Xiang Zhao, Yupeng Zhao, Xiangrui Wang, Lei Hou, Zhongwei Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
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  5. Autophagy in Acute Lung Injury.Cell biochemistry and biophysics · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Zhenzhen Li *Department of Pharmacy, Zhongshan Hospital Wusong Branch, Fudan University, 200940 Shanghai, China.
Beijie Zheng *Department of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 200127 Shanghai, China.
Chenchen LiuDepartment of Anesthesiology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, 200081 Shanghai, China.
Xiang ZhaoDepartment of Surgery of Spine and Spinal Cord, Henan University People's Hospital, Henan Provincial People's Hospital, Henan, Zhengzhou 453003, China.
Yupeng ZhaoDepartment of Anesthesiology and Critical Care Medicine, Shanghai East Hospital, Tongji University School of Medicine, 200120 Shanghai, China.
Xiangrui WangDepartment of Anesthesiology and Critical Care Medicine, Shanghai East Hospital, Tongji University School of Medicine, 200120 Shanghai, China.ORCID https://orcid.org/0000-0003-2224-7672
Lei HouDepartment of Anesthesiology and Critical Care Medicine, Shanghai East Hospital, Tongji University School of Medicine, 200120 Shanghai, China.ORCID https://orcid.org/0000-0002-6048-7274
Zhongwei YangDepartment of Anesthesiology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, 200081 Shanghai, China.ORCID https://orcid.org/0000-0001-7514-826X
Shanghai East Hospital · CNShanghai First People's Hospital · CNHenan University · CNShanghai Jiao Tong University · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type II alveolar epithelial cell (AECII) apoptosis is one of the most vital causes of sepsis-induced acute respiratory distress syndrome (ARDS). Recent evidence has proved that bone mesenchymal stem cell-derived exosomes (BMSC-exos) can effectively reduce sepsis-induced ARDS. However, the function and molecular mechanism of BMSC-exos in sepsis-induced AECII apoptosis remain to be elucidated. In the present study, a more significant number of AECII apoptosis, high mitochondrial fission p-Drp1 protein levels, and low levels of mitochondrial biogenesis-related PGC1

Identifiers

PMID37035447
PMCPMC10081904
OpenAlexW4362470165

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.