Evidence map›Paper›PMID 37035443›Full record

ArticleTetrahedron2023

Synthesis of 4-

Rukshana Mohamad-Ramshan, Chennaiah Ande, Takahiko Matsushita, Klara Haldimann, Andrea Vasella, Sven N Hobbie, David Crich

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tetrahedron, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rukshana Mohamad-RamshanDepartment of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI 48202, USA.
Chennaiah AndeDepartment of Pharmaceutical and Biomedical Sciences, University of Georgia, 250 West Green Street, Athens, GA 30602, USA.
Takahiko MatsushitaDepartment of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI 48202, USA.
Klara HaldimannInstitute of Medical Microbiology, University of Zurich, Gloriastrasse 30, 8006 Zürich, Switzerland.
Andrea VasellaOrganic Chemistry Laboratory, ETH Zürich, Vladimir-Prelog-Weg 1-5/10, 8093 Zürich, Switzerland.
Sven N HobbieInstitute of Medical Microbiology, University of Zurich, Gloriastrasse 30, 8006 Zürich, Switzerland.
David CrichDepartment of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI 48202, USA.

Funding

Shaping Next Generation Aminoglycoside Antibiotics for Treatment of Multidrug-Resistant DiseasesR01AI123352 · NIAID · WAYNE STATE UNIVERSITY · PI CRICH, DAVID · 2016 to 2019
$2.7M
NIAID NIH HHS R01 AI123352
6 · The paper itself

Abstract

The design, synthesis and antiribosomal and antibacterial activity of two novel glycosides of the aminoglycoside antibiotic paromomycin are described. The first carries of 4-amino-4-deoxy-β-D-xylopyranosyl moiety at the paromomycin 4'-position and is approximately two-fold more active than the corresponding β-D-xylopyranosyl derivative. The second is a 4'-(β-D-xylopyranosylthio) derivative of 4'-deoxyparomomycin that is unexpectedly less active than the simple β-D-xylopyranosyl derivative, perhaps because of the insertion of the conformationally more mobile thioglycosidic linkage.

Identifiers

PMID37035443
PMCPMC10081503

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.