Evidence map›Paper›PMID 37035273›Full record

ArticleWorld journal of gastrointestinal pathophysiology2023

Polymorphism of genes encoding drug-metabolizing and inflammation-related enzymes for susceptibility to cholangiocarcinoma in Thailand.

Gyokukou You, Lu Zeng, Hideaki Tanaka, Emi Ohta, Takahiro Fujii, Kazuhiko Ohshima, Masakazu Tanaka, Nobuyuki Hamajima, Chutiwan Viwatthanasittiphong, Mantana Muangphot and 5 more

Open access · diamondAbstract read
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In one paragraph

Article in World journal of gastrointestinal pathophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

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0 citing papers in PubMed, 0 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Gyokukou YouDepartment of Bioscience, Nagahama Institute of Bio-Science and Technology, Nagahama 526-0829, Shiga, Japan.
Lu ZengDepartment of Bioscience, Nagahama Institute of Bio-Science and Technology, Nagahama 526-0829, Shiga, Japan.
Hideaki TanakaDepartment of Bioscience, Nagahama Institute of Bio-Science and Technology, Nagahama 526-0829, Shiga, Japan.
Emi OhtaDepartment of Bioscience, Nagahama Institute of Bio-Science and Technology, Nagahama 526-0829, Shiga, Japan.
Takahiro FujiiDepartment of Bioscience, Nagahama Institute of Bio-Science and Technology, Nagahama 526-0829, Shiga, Japan.
Kazuhiko OhshimaDepartment of Bioscience, Nagahama Institute of Bio-Science and Technology, Nagahama 526-0829, Shiga, Japan.
Masakazu TanakaDivision of Neuroimmunology, Joint Research Center for Human Retrovirus Infection, Kagoshima University, Kagoshima 890-8544, Kagoshima, Japan.
Nobuyuki HamajimaDepartment of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Aichi, Japan.
Chutiwan ViwatthanasittiphongDepartment of Diagnostic and Interventional Radiology, Ubon Cancer Centre, Ubon Ratchathani 34000, Thailand.
Mantana MuangphotDepartment of Pathology, Ubon Cancer Centre, Ubon Ratchathani 34000, Thailand.
Dhiraphol ChenvidhyaDepartment of Surgery, Ubon Cancer Centre, Ubon Ratchathani 34000, Thailand.
Adisorn JedpiyawongseResearch Division, National Cancer Institute, Bangkok 10400, Thailand.
Banchob SripaDepartment of Pathology, Khon Kaen University, Khon Kaen 40002, Thailand.
Masanao MiwaDepartment of Bioscience, Nagahama Institute of Bio-Science and Technology, Nagahama 526-0829, Shiga, Japan.
Satoshi HonjoDepartment of Paediatirics, National Hospital Organization, Fukuoka National Hospital, Fukuoka 811-1394, Fukuoka, Japan. satoshihonjo@hotmail.com.
Kagoshima University · JPKhon Kaen University · THNational Cancer Institute of Thailand · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCholangiocarcinoma (CCA) is an intractable cancer, and its incidence in northeastern Thailand is the highest worldwide. Infection with the liver fluke

aimTo examine relations between risk for CCA and genetic polymorphisms in carcinogen-metabolizing and inflammation-related genes.

methodsThis hospital-based case-control study enrolled 95 case-control pairs matched by age (± 5 years) and sex. We examined relations between risk for CCA and genetic polymorphisms in carcinogen-metabolizing and inflammation-related genes, serum anti-OV, alcohol consumption, and smoking. Polymorphisms of

resultsAlthough CCA risk was not significantly associated with any single polymorphism, persons with the

conclusionIn addition to infection with OV, gene-gene interactions may be considered as one of the risk factors for CCA development.

Indexed as

Case-control studyCytochrome P-450 CYP2E1Glutathione transferaseOpisthorchis

Identifiers

PMID37035273
PMCPMC10074948
OpenAlexW4327904942

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.