Evidence map›Paper›PMID 37035097›Full record

ReviewTherapeutic advances in chronic disease2023

The emerging role of noncoding RNAs in systemic lupus erythematosus: new insights into the master regulators of disease pathogenesis.

Mina Afrashteh Nour, Farid Ghorbaninezhad, Zahra Asadzadeh, Amir Baghbanzadeh, Hamidreza Hassanian, Patrizia Leone, Mahdi Jafarlou, Nazila Alizadeh, Vito Racanelli, Behzad Baradaran

Open access · goldAbstract readReview
In one paragraph

Review in Therapeutic advances in chronic disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Mina Afrashteh NourImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Farid GhorbaninezhadImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Zahra AsadzadehImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Amir BaghbanzadehImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Hamidreza HassanianStudent Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Patrizia LeoneDepartment of Interdisciplinary Medicine, University of Bari 'Aldo Moro', Bari, Italy.
Mahdi JafarlouImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Nazila AlizadehImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Vito RacanelliDepartment of Interdisciplinary Medicine, University of Bari 'Aldo Moro', 70124, Bari, Italy.
Behzad BaradaranImmunology Research Center, Tabriz University of Medical Sciences, Daneshgah Street, Tabriz, Iran.ORCID https://orcid.org/0000-0002-8642-6795
Tabriz University of Medical Sciences · IRUniversity of Bari Aldo Moro · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Auto-immune diseases are a form of chronic disorders in which the immune system destroys the body's cells due to a loss of tolerance to self-antigens. Systemic lupus erythematosus (SLE), identified by the production of autoantibodies in different body parts, is one of the most well-known examples of these diseases. Although the etiology of SLE is unclear, the disease's progression may be affected by genetic and environmental factors. As studies in twins provide adequate evidence for genetic involvement in the SLE, other phenomena such as metallization, histone modifications, and alterations in the expression of noncoding RNAs (ncRNAs) also indicate the involvement of epigenetic factors in this disease. Among all the epigenetic alterations, ncRNAs appear to have the most crucial contribution to the pathogenesis of SLE. The ncRNAs' length and size are divided into three main classes: micro RNAs, long noncoding RNAs (LncRNA), and circular RNAs (circRNAs). Accumulating evidence suggests that dysregulations in these ncRNAs contributed to the pathogenesis of SLE. Hence, clarifying the function of these groups of ncRNAs in the pathophysiology of SLE provides a deeper understanding of the disease. It also opens up new opportunities to develop targeted therapies for this disease.

Indexed as

auto-immune diseaseauto-immunitycircular RNAsLncRNAsmicro RNAsnoncoding RNAsystemic lupus erythematosus

Identifiers

PMID37035097
PMCPMC10074641
OpenAlexW4362569504

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.