Evidence map›Paper›PMID 37034838›Full record

ArticleJournal of dental anesthesia and pain medicine2023

Comparative evaluation of intranasal midazolam-ketamine, dexmedetomidine-ketamine, midazolam-fentanyl, and dexmedetomidine-fentanyl combinations for procedural sedation and analgesia in pediatric dental patients: a randomized controlled trial.

Abhilasha Agarwal, Afroz Alam Ansari, Rajendra Nath, Rakesh Kumar Chak, Rajeev Kumar Singh, Richa Khanna, Prem Raj Singh

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of dental anesthesia and pain medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 3 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 3 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Efficacy of Midazolam in Outpatient Pediatric Dentistry: A Systematic Review.Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry
    Pooled it
  4. Trial
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Abhilasha AgarwalDepartment of Pediatric and Preventive dentistry, Faculty of Dental Sciences, King George Medical University, U.P., Lucknow, India.ORCID https://orcid.org/0000-0002-3841-0676
Afroz Alam AnsariDepartment of Pediatric and Preventive dentistry, Faculty of Dental Sciences, King George Medical University, U.P., Lucknow, India.ORCID https://orcid.org/0000-0002-7916-4758
Rajendra NathDepartment of Pharmacology & Therapeutics, King George Medical University, U.P., Lucknow, India.ORCID https://orcid.org/0000-0002-2373-693X
Rakesh Kumar ChakDepartment of Pediatric and Preventive dentistry, Faculty of Dental Sciences, King George Medical University, U.P., Lucknow, India.ORCID https://orcid.org/0000-0002-4652-6791
Rajeev Kumar SinghDepartment of Pediatric and Preventive dentistry, Faculty of Dental Sciences, King George Medical University, U.P., Lucknow, India.ORCID https://orcid.org/0000-0002-1348-1750
Richa KhannaDepartment of Pediatric and Preventive dentistry, Faculty of Dental Sciences, King George Medical University, U.P., Lucknow, India.ORCID https://orcid.org/0000-0001-6830-8042
Prem Raj SinghDepartment of Department of Anesthesiology and Critical Care, King George Medical University, U.P., Lucknow, India.ORCID https://orcid.org/0000-0002-5346-6619
King George's Medical University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: In order to assess the effectiveness of various analgesio-sedative combinations for pain relief and sedation in pediatric dental patients, a thorough evaluation of clinical studies and patient outcomes is necessary. Methods: A total of 128 healthy, uncooperative pediatric dental patients were randomly allocated to receive one of the four combinations of drugs via the intranasal (IN) route: Group I received midazolam-ketamine (MK), Group II received dexmedetomidine-ketamine (DK), Group III received midazolam-fentanyl (MF), and Group IV received dexmedetomidine-fentanyl (DF) in a parallel-arm study design. The efficacy and safety of the combinations were evaluated using different parameters. Results: The onset of sedation was significantly faster in the DF group than in the DK, MF, and MK groups (P < 0.001). The depth of sedation was significantly higher in the DK and DF groups than in the MK and MF groups (P < 0.01). DK and DF produced significant intra- and postoperative analgesia when compared with combinations of MK and MF. No significant adverse events were observed for any of the combinations. Conclusions: The DK and DF groups showed potential as analgesio-sedatives in view of their anxiolytic and analgesic effects.

Indexed as

Analgesio-sedationDental anxietyDexmedetomidineFentanylKetamineMidazolam

Identifiers

PMID37034838
PMCPMC10079769
OpenAlexW4362595304

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.