Evidence map›Paper›PMID 37034812›Full record

ArticlebioRxiv : the preprint server for biology2023

Direct Thalamic Inputs to Hippocampal CA1 Transmit a Signal That Suppresses Ongoing Contextual Fear Memory Retrieval.

Heather C Ratigan, Seetha Krishnan, Shai Smith, Mark E J Sheffield

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Heather C RatiganDepartment of Neurobiology, University of Chicago, Chicago, IL 60615, USA.
Seetha KrishnanDepartment of Neurobiology, University of Chicago, Chicago, IL 60615, USA.
Shai SmithDepartment of Neurobiology, University of Chicago, Chicago, IL 60615, USA.
Mark E J SheffieldDepartment of Neurobiology, University of Chicago, Chicago, IL 60615, USA.
University of Chicago · US

Funding

Integrative Training in the Neurobiology of Addictive BehaviorsT32DA043469 · NIDA · UNIVERSITY OF CHICAGO · PI Donald Hedeker, Xiaoxi Zhuang · 2017 to 2026
$3.8M
Sub-cellular resolution functional imaging and optogenetic manipulation of identified memory circuits during behaviorDP2NS111657 · NINDS · UNIVERSITY OF CHICAGO · PI SHEFFIELD, MARK E J · 2018 to 2018
$2.4M
From synapses to neural representations: The role of neuromodulatory circuits in shaping contextual memories in the hippocampusRF1NS127123 · NINDS · UNIVERSITY OF CHICAGO · PI SHEFFIELD, MARK E J · 2022 to 2022
$1.9M
NIDA NIH HHS T32 DA043469NINDS NIH HHS DP2 NS111657NINDS NIH HHS RF1 NS127123
6 · The paper itself

Abstract

Memory retrieval of fearful experiences is essential for survival but can be maladaptive if not appropriately suppressed. Fear memories can be acquired through contextual fear conditioning (CFC) which relies on the hippocampus. The thalamic subregion Nucleus Reuniens (NR) is necessary for contextual fear extinction and strongly projects to hippocampal subregion CA1. However, the NR-CA1 pathway has not been investigated during behavior, leaving unknown its role in contextual fear memory retrieval. We implement a novel head-restrained virtual reality CFC paradigm and show that inactivation of the NR-CA1 pathway prolongs fearful freezing epochs, induces fear generalization, and delays extinction. We use

Identifiers

PMID37034812
PMCPMC10081195
OpenAlexW4360990939

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.