Evidence map›Paper›PMID 37034758›Full record

ArticleResearch square2023

Biochemical activity induced by a germline variation in

Srilakshmi Srinivasan, Thomas Kryza, Nathalie Bock, Brian Wc Tse, Kamil A Sokolowski, Janaththani Panchadsaram, Leire Moya, Carson Stephens, Ying Dong, Joan Röhl and 60 more

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

70 authors at 1 institution in 1 country.

Srilakshmi SrinivasanSchool of Biomedical Sciences, Faculty of Health, Queensland University of Technology (QUT).
Thomas KryzaMater Research Institute - The University of Queensland, Translational Research Institute, Woolloongabba, Brisbane, QLD, Australia.
Nathalie BockSchool of Biomedical Sciences, Faculty of Health, Queensland University of Technology (QUT).
Brian Wc TsePreclinical Imaging Facility, Translational Research Institute, Woolloongabba, Brisbane, QLD, Australia.
Kamil A SokolowskiPreclinical Imaging Facility, Translational Research Institute, Woolloongabba, Brisbane, QLD, Australia.
Janaththani PanchadsaramSchool of Biomedical Sciences, Faculty of Health, Queensland University of Technology (QUT).
Leire MoyaSchool of Biomedical Sciences, Faculty of Health, Queensland University of Technology (QUT).
Carson StephensSchool of Biomedical Sciences, Faculty of Health, Queensland University of Technology (QUT).
Ying DongSchool of Biomedical Sciences, Faculty of Health, Queensland University of Technology (QUT).
Joan RöhlSchool of Biomedical Sciences, Faculty of Health, Queensland University of Technology (QUT).
Saeid AlinezhadSchool of Biomedical Sciences, Faculty of Health, Queensland University of Technology (QUT).
Ian VelaSchool of Biomedical Sciences, Faculty of Health, Queensland University of Technology (QUT).
Joanna L Perry-KeenePathology Queensland, Sunshine Coast University Hospital Laboratory, Birtinya, Sunshine Coast, QLD, Australia.
Katie BuzacottPathology Queensland, Sunshine Coast University Hospital Laboratory, Birtinya, Sunshine Coast, QLD, Australia.
IMPACT Study
Manuela Gago-DominguezGenomic Medicine Group, Galician Foundation of Genomic Medicine, IDIS, Complejo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain.
PROFILE Study Steering Committee
Johanna SchleutkerInstitute of Biomedicine, Kiinamyllynkatu 10, FI-20014 University of Turku, Finland.
Christiane MaierHumangenetik Tuebingen, Paul-Ehrlich-Str 23, D-72076 Tuebingen, Germany.
Kenneth MuirDivision of Population Health, Health Services Research and Primary Care, University of Manchester, Manchester, M13 9PL, UK.
Catherine M TangenSWOG Statistical Center, Division of Public Health Sciences.
Henrik GronbergDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
Nora PashayanDepartment of Applied Health Research, University College London, London, UK.
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, USA.
Alicja WolkDivision of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Janet L StanfordDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109-1024, USA.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, USA.
Lorelei A MucciDepartment of Epidemiology,Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
Stella KoutrosDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, USA.
Olivier CussenotCeRePP and Sorbonne Universite, GRC N°5 AP-HP, Tenon Hospital, Paris, France.
Karina Dalsgaard SorensenDepartment of Molecular Medicine, Aarhus University Hospital, Aarhus N, Denmark.
Eli Marie GrindedalDepartment of Medical Genetics, Oslo University Hospital, Oslo, Norway.
Timothy J KeyCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Christopher A HaimanCenter for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, USA.
Graham G GilesCancer Epidemiology & Intelligence Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
Ana VegaFundación Pública Galega de Medicina Xenómica-SERGAS, Instituto de Investigación Sanitaria (IDIS), Santiago de Compostela, Spain.
Fredrik WiklundDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
David E NealNuffield Department of Surgical Sciences, University of Oxford, Oxford, England.
Manolis KogevinasISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.
Meir J StampferChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
Børge G NordestgaardFaculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Marija GamulinDivision of Medical Oncology, Urogenital Unit, Department of Oncology, University Hospital Centre Zagreb, Zagreb, Croatia.
Frank ClaessensMolecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Belgium.
Olle MelanderDepartment of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
Anders DahlinDepartment of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
Pär StattinDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Göran HallmansDepartment of Public Health and Clinical Medicine, Nutritional Research, Umeå University, Umeå, Sweden.
Christel HäggströmDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Robert JohanssonDepartment of Biobank Research, Umeå University, Umeå, Sweden.
Elin ThysellDepartment of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden.
Ann-Charlotte RönnClinical Research Center, Karolinska University Hospital, Huddinge, Sweden.
Weiqiang LiIcahn Institute for Data Science and Genome Technology, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nigel BrownDepartment of Chemical Pathology, Pathology Queensland, Princess Alexandra Hospital, Woolloongabba, Brisbane, QLD, Australia.
Goce DimeskiDepartment of Chemical Pathology, Pathology Queensland, Princess Alexandra Hospital, Woolloongabba, Brisbane, QLD, Australia.
Benjamin ShepherdDepartment of Anatomical Pathology, Pathology Queensland, Princess Alexandra Hospital, Woolloongabba, Brisbane, QLD, Australia.
Tokhir DadaevThe Institute of Cancer Research, London, SM2 5NG, UK.
Mark N BrookThe Institute of Cancer Research, London, SM2 5NG, UK.
Amanda B SpurdleMolecular Cancer Epidemiology Laboratory, QIMR Berghofer Medical Research Institute, Herston, Brisbane, QLD, Australia.
Ulf-Håkan StenmanDepartment of Clinical Chemistry, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Hannu KoistinenDepartment of Clinical Chemistry, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Zsofia Kote-JaraiThe Institute of Cancer Research, London, SM2 5NG, UK.
Robert J KleinIcahn Institute for Data Science and Genome Technology, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Hans LiljaNuffield Department of Surgical Sciences, University of Oxford, Oxford, England.
Rupert C EckerSchool of Biomedical Sciences, Faculty of Health, Queensland University of Technology (QUT).
Rosalind EelesThe Institute of Cancer Research, London, SM2 5NG, UK.
Practical Consortium
Australian Prostate Cancer BioResource
Judith ClementsSchool of Biomedical Sciences, Faculty of Health, Queensland University of Technology (QUT).
Jyotsna BatraSchool of Biomedical Sciences, Faculty of Health, Queensland University of Technology (QUT).
Translational Research Institute · AU

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Elisa de Stanchina · 1985 to 2026
$347.4M
SPORE In Prostate CancerP50CA092629 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI JAMES A EASTHAM · 2001 to 2026
$63.0M
Improving prostate cancer screening by integration of SNPs with blood biomarkersR01CA175491 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI KLEIN, ROBERT J. · 2013 to 2018
$2.8M
Cancer Research UK 13232Cancer Research UK 14835Cancer Research UK 15007Cancer Research UK 17528Cancer Research UK 21332Cancer Research UK 22530Cancer Research UK 29017NCI NIH HHS P30 CA008748NCI NIH HHS P50 CA092629NCI NIH HHS R01 CA175491Prostate Cancer UK G2011/36Prostate Cancer UK G2012/48Prostate Cancer UK PG13-001
6 · The paper itself

Abstract

Genetic variation at the 19q13.3

Indexed as

diagnosisdisease aggressivenessKallikrein-related peptidase 3/KLK3Prostate cancerprostate-specific antigen/PSAsingle nucleotide polymorphism

Identifiers

PMID37034758
PMCPMC10081352
OpenAlexW4361209823

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.