Evidence map›Paper›PMID 37034756›Full record

ArticlebioRxiv : the preprint server for biology2023

Apical PAR-3 caps orient the mitotic spindle in

Naomi J Stolpner, Nadia I Manzi, Thomas Su, Daniel J Dickinson

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Naomi J StolpnerDepartment of Molecular Biosciences, The University of Texas at Austin, 2415 Speedway, PAT 206, Austin, TX 78712.
Nadia I ManziDepartment of Molecular Biosciences, The University of Texas at Austin, 2415 Speedway, PAT 206, Austin, TX 78712.
Thomas SuDepartment of Molecular Biosciences, The University of Texas at Austin, 2415 Speedway, PAT 206, Austin, TX 78712.
Daniel J DickinsonDepartment of Molecular Biosciences, The University of Texas at Austin, 2415 Speedway, PAT 206, Austin, TX 78712.
The University of Texas at Austin · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Understanding developmental control of cell polarity using single-cell in vivo biochemistryR01GM138443 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI DICKINSON, DANIEL J · 2020 to 2025
$2.4M
Biochemical Basis of Cell Polarization by the PAR Protein SystemR00GM115964 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI DICKINSON, DANIEL J · 2018 to 2020
$747k
How a cell cycle kinase, Aurora A, regulates polarity proteins organizationF31HD108006 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI MANZI, NADIA INGABIRE · 2022 to 2024
$94k
NICHD NIH HHS F31 HD108006NIGMS NIH HHS R00 GM115964NIGMS NIH HHS R01 GM138443NIH HHS P40 OD010440
6 · The paper itself

Abstract

During embryonic development, oriented cell divisions are important for patterned tissue growth and cell fate specification. Cell division orientation is controlled in part by asymmetrically localized polarity proteins, which establish functional domains of the cell membrane and interact with microtubule regulators to position the mitotic spindle. For example, in the 8-cell mouse embryo, apical polarity proteins form caps on the outside, contact-free surface of the embryo that position the mitotic spindle to execute asymmetric cell division. A similar radial or "inside-outside" polarity is established at an early stage in many other animal embryos, but in most cases it remains unclear how inside-outside polarity is established and how it influences downstream cell behaviors. Here, we explore inside-outside polarity in

Identifiers

PMID37034756
PMCPMC10081169
OpenAlexW4360991056

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.