Evidence map›Paper›PMID 37034740›Full record

ArticlebioRxiv : the preprint server for biology2023

Replicative stress in gastroesophageal adenocarcinoma is associated with chromosomal instability and sensitivity to DNA damage response inhibitors.

Pranshu Sahgal, Deepa T Patil, Zsofia M Sztupinszki, Viktoria Tisza, Sandor Spisak, Brandon Huffman, Aurel Prosz, Harshabad Singh, Jean-Bernard Lazaro, Zoltan Szallasi and 2 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Pranshu SahgalDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
Deepa T PatilDepartment of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA.
Zsofia M SztupinszkiDanish Cancer Society Research Center, Copenhagen, 2100, Denmark.
Viktoria TiszaDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
Sandor SpisakDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
Brandon HuffmanDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
Aurel ProszDanish Cancer Society Research Center, Copenhagen, 2100, Denmark.
Harshabad SinghDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
Jean-Bernard LazaroDepartment of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
Zoltan SzallasiDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
James M ClearyDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
Nilay S SethiDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
Brigham and Women's Hospital · USDana-Farber Cancer Institute · USBroad Institute · USDanish Cancer Society · DK

Funding

Integration of early genetic alterations and inflammation in gastroesophageal premalignancyK08DK120930 · NIDDK · DANA-FARBER CANCER INST · PI SETHI, NILAY · 2019 to 2023
$790k
NIDDK NIH HHS K08 DK120930
6 · The paper itself

Abstract

Gastroesophageal adenocarcinoma (GEA) is an aggressive, often lethal, malignancy that displays marked chromosomal instability (CIN). To understand adaptive responses that enable CIN, we analyzed paired normal, premalignant, and malignant gastric lesions from human specimens and a carcinogen-induced mouse model, observing activation of replication stress, DNA damage response (DDR), and cell cycle regulator p21 in neoplastic progression. In GEA cell lines, expression of DDR markers correlated with ploidy abnormalities, including high-level focal amplifications and whole-genome duplication (WGD). Moreover, high expression of DNA damage marker

Indexed as

aneuploidyCINDNA-damage responseDNA damage response pathway inhibitorsesophageal cancerGastric canceririnotecanreplication stress

Identifiers

PMID37034740
PMCPMC10081209
OpenAlexW4361218938

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.