Evidence map›Paper›PMID 37034693›Full record

ArticlebioRxiv : the preprint server for biology2023

Mathematical modeling suggests cytotoxic T lymphocytes control growth of B16 tumor cells in collagin-fibrin gels by cytolytic and non-lytic mechanisms.

Barun Majumder, Sadna Budhu, Vitaly V Ganusov

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Barun MajumderDepartment of Microbiology, University of Tennessee, Knoxville, TN 37996, USA.
Sadna BudhuDepartment of Pharmacology, Weill Cornell Medicine, New York, NY 10021, USA.
Vitaly V GanusovDepartment of Microbiology, University of Tennessee, Knoxville, TN 37996, USA.
University of Tennessee at Knoxville · USCornell University · US

Funding

Mathematical modeling of Mycobacterium tuberculosis disseminationR01AI158963 · NIAID · UNIVERSITY OF TENNESSEE KNOXVILLE · PI Vitaly V. Ganusov · 2022 to 2026
$3.2M
Mathematical modeling of immune response to malariaR01GM118553 · NIGMS · UNIVERSITY OF TENNESSEE KNOXVILLE · PI GANUSOV, VITALY V. · 2017 to 2021
$1.6M
NIAID NIH HHS R01 AI158963NIGMS NIH HHS R01 GM118553
6 · The paper itself

Abstract

Cytotoxic T lymphocytes (CTLs) are important in controlling some viral infections, and therapies involving transfer of large numbers of cancer-specific CTLs have been successfully used to treat several types of cancers in humans. While molecular mechanisms of how CTLs kill their targets are relatively well understood we still lack solid quantitative understanding of the kinetics and efficiency at which CTLs kill their targets in different conditions. Collagen-fibrin gel-based assays provide a tissue-like environment for the migration of CTLs, making them an attractive system to study the cytotoxicity in vitro. Budhu

Identifiers

PMID37034693
PMCPMC10081166
OpenAlexW4361228094

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.