Evidence map›Paper›PMID 37034676›Full record

ArticlebioRxiv : the preprint server for biology2023

Deep repertoire mining uncovers ultra-broad coronavirus neutralizing antibodies targeting multiple spike epitopes.

Jonathan Hurtado, Thomas F Rogers, David B Jaffe, Bruce A Adams, Sandhya Bangaru, Elijah Garcia, Tazio Capozzola, Terrence Messmer, Pragati Sharma, Ge Song and 10 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 1 country.

Jonathan HurtadoDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Thomas F RogersDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
David B Jaffe10x Genomics, Inc. 6230 Stoneridge Mall Road, Pleasanton, CA 94588, USA.
Bruce A Adams10x Genomics, Inc. 6230 Stoneridge Mall Road, Pleasanton, CA 94588, USA.
Sandhya BangaruDepartment of Integrative Structural and Computational Biology, Scripps Research, La Jolla, CA 92037, USA.
Elijah GarciaDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Tazio CapozzolaDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Terrence MessmerDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Pragati SharmaDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Ge SongDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Nathan BeutlerDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Wanting HeDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Katharina DuekerDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Rami MusharrafiehDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Michael J T Stubbington10x Genomics, Inc. 6230 Stoneridge Mall Road, Pleasanton, CA 94588, USA.
Dennis R BurtonDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Raiees AndrabiDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Andrew B WardDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Wyatt J McDonnell10x Genomics, Inc. 6230 Stoneridge Mall Road, Pleasanton, CA 94588, USA.
Bryan BrineyDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Scripps Research Institute · US10X Genomics (United States) · USScripps Institution of Oceanography · US

Funding

Identification of neutralizing epitopes on SARS-CoV-2 spike for design of vaccines and small-molecule antiviralsUM1AI144462 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI BURTON, DENNIS R. · 2019 to 2025
$201.6M
Technology CoreU19AI135995 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI Laura D. Hughes · 2018 to 2026
$32.0M
The Multi-omics Vaccine Evaluation (MOVE) ConsortiumP01AI177683 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI Bryan Briney · 2023 to 2026
$9.0M
Development of pan-betacoronavirus vaccinesR01AI170928 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Raiees Ahmad Andrabi · 2023 to 2026
$3.0M
High-resolution deconvolution of selection effects on the composition of the B cell repertoireR35GM133682 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI BRINEY, BRYAN · 2019 to 2023
$2.4M
NIAID NIH HHS P01 AI177683NIAID NIH HHS R01 AI170928NIAID NIH HHS U19 AI135995NIAID NIH HHS UM1 AI144462NIGMS NIH HHS R35 GM133682
6 · The paper itself

Abstract

Development of vaccines and therapeutics that are broadly effective against known and emergent coronaviruses is an urgent priority. Current strategies for developing pan-coronavirus countermeasures have largely focused on the receptor binding domain (

Identifiers

PMID37034676
PMCPMC10081229
OpenAlexW4361283865

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.