Evidence map›Paper›PMID 37034651›Full record

ArticlebioRxiv : the preprint server for biology2023

FLASH-RT does not affect chromosome translocations and junction structures beyond that of CONV-RT dose-rates.

Paul G Barghouth, Stavros Melemenidis, Pierre Montay-Gruel, Jonathan Ollivier, Vignesh Viswanathan, Patrik G Jorge, Luis A Soto, Brianna C Lau, Cheyenne Sadeghi, Anushka Edlabadkar and 12 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 4 institutions in 2 countries.

Paul G BarghouthDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Stavros MelemenidisDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Pierre Montay-GruelLaboratory of Radiation Oncology, Department of Radiation Oncology. Lausanne University Hospital and University of Lausanne, Switzerland.
Jonathan OllivierLaboratory of Radiation Oncology, Department of Radiation Oncology. Lausanne University Hospital and University of Lausanne, Switzerland.
Vignesh ViswanathanDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Patrik G JorgeInstitute of Radiation Physics/CHUV, Lausanne University Hospital, Switzerland.
Luis A SotoDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Brianna C LauDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Cheyenne SadeghiDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Anushka EdlabadkarDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Rakesh ManjappaDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Jinghui WangDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Marie Le BouteillerDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Murat SurucuDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Amy YuDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Karl BushDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Lawrie SkinnerDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Peter G MaximDepartment of Radiation Oncology, University of California, Irvine, CA 92697-2695, USA.
Billy W LooDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Charles L LimoliDepartment of Radiation Oncology, University of California, Irvine, CA 92697-2695, USA.
Marie-Catherine VozeninLaboratory of Radiation Oncology, Department of Radiation Oncology. Lausanne University Hospital and University of Lausanne, Switzerland.
Richard L FrockDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Stanford University · USUniversity of California, Irvine · USUniversity of Lausanne · CHInstitute of Radiation Physics

Funding

Project 4: Mechanistic Basics of FLASH Effect: Role of O2P01CA244091 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI LIMOLI, CHARLES · 2020 to 2024
$9.6M
Postdoctoral Training in the Radiation ScincesT32CA121940 · NCI · STANFORD UNIVERSITY · PI GRAVES, EDWARD E. · 2007 to 2018
$2.1M
NCI NIH HHS P01 CA244091NCI NIH HHS T32 CA121940
6 · The paper itself

Abstract

The molecular and cellular mechanisms driving the enhanced therapeutic ratio of ultra-high dose-rate radiotherapy (FLASH-RT) over slower conventional (CONV-RT) radiotherapy dose-rate remain to be elucidated. However, attenuated DNA damage and transient oxygen depletion are among several proposed models. Here, we tested whether FLASH-RT under physioxic (4% O

Identifiers

PMID37034651
PMCPMC10081175
OpenAlexW4361212724

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.