Evidence map›Paper›PMID 37034633›Full record

ArticlebioRxiv : the preprint server for biology2023

Dopamine D1 and NMDA receptor co-regulation of protein translation in cultured nucleus accumbens neurons.

Alexa R Zimbelman, Benjamin Wong, Conor H Murray, Marina E Wolf, Michael T Stefanik

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Alexa R ZimbelmanDepartment of Psychology and Neuroscience, North Central College, Naperville, IL 60540.
Benjamin WongDepartment of Psychology and Neuroscience, North Central College, Naperville, IL 60540.
Conor H MurrayDepartment of Neuroscience, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, IL, 60064.
Marina E WolfDepartment of Neuroscience, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, IL, 60064.ORCID 0000-0001-9129-3432
Michael T StefanikDepartment of Psychology and Neuroscience, North Central College, Naperville, IL 60540.ORCID 0000-0002-8025-3440
North Central College · USRosalind Franklin University of Medicine and Science · USOregon Health & Science University · US

Funding

Dopamine and Glutamate Receptor InteractionsR37DA015835 · NIDA · ROSALIND FRANKLIN UNIV OF MEDICINE &SCI · PI WOLF, MARINA ELIZABETH · 2003 to 2012
$2.8M
Synaptic mechanisms maintaining persistent cocaine craving.R01DA015835 · NIDA · ROSALIND FRANKLIN UNIV OF MEDICINE & SCI · PI WOLF, MARINA ELIZABETH · 2014 to 2018
$1.8M
Protein translation and the incubation of cocaine cravingF32DA040414 · NIDA · ROSALIND FRANKLIN UNIV OF MEDICINE & SCI · PI STEFANIK, MICHAEL THOMAS · 2015 to 2017
$164k
NIDA NIH HHS F32 DA040414NIDA NIH HHS R01 DA015835NIDA NIH HHS R37 DA015835
6 · The paper itself

Abstract

Protein translation is essential for some forms of synaptic plasticity. We used nucleus accumbens (NAc) medium spiny neurons (MSN), co-cultured with cortical neurons to restore excitatory synapses, to examine whether dopamine modulates protein translation in NAc MSN. FUNCAT was used to measure translation in MSNs under basal conditions and after disinhibiting excitatory transmission using the GABA

Indexed as

DopamineFUNCATNMDA receptorProtein translationProximity Ligation Assay

Identifiers

PMID37034633
PMCPMC10081306
OpenAlexW4362460681

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.