Evidence map›Paper›PMID 37034631›Full record

ArticlebioRxiv : the preprint server for biology2023

Activity-dependent constraints on catecholamine signaling.

Li Li, Akshay Rana, Esther M Li, Jiesi Feng, Yulong Li, Michael R Bruchas

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Li LiDepartment of Anesthesiology & Pain Medicine, University of Washington, Seattle, WA 98195, USA.
Akshay RanaDepartment of Anesthesiology & Pain Medicine, University of Washington, Seattle, WA 98195, USA.
Esther M LiDepartment of Anesthesiology & Pain Medicine, University of Washington, Seattle, WA 98195, USA.
Jiesi FengState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China.
Yulong LiState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China.
Michael R BruchasDepartment of Anesthesiology & Pain Medicine, University of Washington, Seattle, WA 98195, USA.
University of Washington · USPeking University · CNSeattle Children's Hospital · US

Funding

Decoding Locus Coeruleus Neural Circuits and Signaling In Negative AffectR01MH112355 · NIMH · WASHINGTON UNIVERSITY · PI Michael R. Bruchas · 2016 to 2026
$5.3M
Unraveling the Locus Coeruleus Circuitry in Opioidinduced Sleep DisturbancesR00DA053336 · NIDA · SEATTLE CHILDREN'S HOSPITAL · PI LI, LI · 2023 to 2025
$747k
Unraveling the Locus Coeruleus Circuitry in Opioidinduced Sleep DisturbancesK99DA053336 · NIDA · UNIVERSITY OF WASHINGTON · PI LI, LI · 2021 to 2022
$350k
NIDA NIH HHS K99 DA053336NIDA NIH HHS R00 DA053336NIMH NIH HHS R01 MH112355
6 · The paper itself

Abstract

Catecholamine signaling is thought to modulate cognition in an inverted-U relationship, but the mechanisms are unclear. We measured norepinephrine and dopamine release, postsynaptic calcium responses, and interactions between tonic and phasic firing modes under various stimuli and conditions. High tonic activity

Identifiers

PMID37034631
PMCPMC10081217
OpenAlexW4361994593

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.