Evidence map›Paper›PMID 37034607›Full record

ArticlebioRxiv : the preprint server for biology2023

Reduced histone gene copy number disrupts

Jeanne-Marie E McPherson, Lucy C Grossmann, Robin L Armstrong, Esther Kwon, Harmony R Salzler, A Gregory Matera, Daniel J McKay, Robert J Duronio

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jeanne-Marie E McPhersonCurriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC, 27599 USA.
Lucy C GrossmannDepartment of Biology, University of North Carolina, Chapel Hill, NC, 27599, USA.
Robin L ArmstrongCurriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC, 27599 USA.
Esther KwonDepartment of Biology, University of North Carolina, Chapel Hill, NC, 27599, USA.
Harmony R SalzlerDepartment of Biology, University of North Carolina, Chapel Hill, NC, 27599, USA.
A Gregory MateraCurriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC, 27599 USA.
Daniel J McKayCurriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC, 27599 USA.
Robert J DuronioCurriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC, 27599 USA.
University of North Carolina at Chapel Hill · US

Funding

NRSA IN GENETICST32GM007092 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SEKELSKY, JEFF J. · 1985 to 2019
$5.9M
NRSA in GeneticsT32GM135128 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Daniel J McKay, JEFF J. SEKELSKY · 2020 to 2026
$5.1M
Role of histone PTMs in epigenetic control of metazoan transcription and RNA processingR35GM136435 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI A. Gregory Matera · 2020 to 2026
$4.7M
Genetic and epigenetic mechanisms of developmental gene regulationR35GM128851 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Daniel J McKay · 2018 to 2026
$3.9M
Epigenetic Control of the Cell Cycle During Animal DevelopmentR35GM145258 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Robert J Duronio · 2022 to 2026
$2.3M
NIGMS NIH HHS R35 GM128851NIGMS NIH HHS R35 GM136435NIGMS NIH HHS R35 GM145258NIGMS NIH HHS T32 GM007092NIGMS NIH HHS T32 GM135128
6 · The paper itself

Abstract

The chromatin of animal cells contains two types of histones: canonical histones that are expressed during S phase of the cell cycle to package the newly replicated genome, and variant histones with specialized functions that are expressed throughout the cell cycle and in non-proliferating cells. Determining whether and how canonical and variant histones cooperate to regulate genome function is integral to understanding how chromatin-based processes affect normal and pathological development. Here, we demonstrate that variant histone H3.3 is essential for

Identifiers

PMID37034607
PMCPMC10081267
OpenAlexW4361228296

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.