Evidence map›Paper›PMID 37034426›Full record

ArticleTetrahedron2023

The Analysis of Two Distinct Strategies toward the Enantioselective Formal Total Synthesis of (+)-Gelsenicine.

Haofan Ji, Phil C Knutson, Christopher M Harrington, Yan-Ting Ke, Eric M Ferreira

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tetrahedron, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Haofan JiDepartment of Chemistry, University of Georgia, Athens, Georgia 30602, United States.
Phil C KnutsonDepartment of Chemistry, University of Georgia, Athens, Georgia 30602, United States.
Christopher M HarringtonDepartment of Chemistry, University of Georgia, Athens, Georgia 30602, United States.
Yan-Ting KeDepartment of Chemistry, University of Georgia, Athens, Georgia 30602, United States.
Eric M FerreiraDepartment of Chemistry, University of Georgia, Athens, Georgia 30602, United States.

Funding

Building Molecular Complexity through Alkyne TransformationsR01GM110560 · NIGMS · UNIVERSITY OF GEORGIA · PI FERREIRA, ERIC M · 2014 to 2019
$1.4M
Purchase of a Thermo Fisher Scientific LTQ Orbitrap XL Mass SpectrometerS10RR028859 · NCRR · UNIVERSITY OF GEORGIA · PI AMSTER, I JONATHAN · 2011 to 2011
$832k
NCRR NIH HHS S10 RR028859NIGMS NIH HHS R01 GM110560
6 · The paper itself

Abstract

A full account of a formal enantioselective total synthesis of (+)-gelsenicine is described. Separate strategies based on catalytic cycloisomerization as the central step are considered. One plan involves chirality transfer from enantioenriched substrates, while the other employs asymmetric catalysis. The chirality transfer strategy is less effective, while in the latter, phosphoramidite- and bisphosphine-gold complexes are tested and ultimately provide a key intermediate in high enantiopurity in our

Indexed as

Alkyne activationAsymmetric catalysisChirality transferGelsenicineGold

Identifiers

PMID37034426
PMCPMC10077972

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.