Evidence map›Paper›PMID 37034382›Full record

ArticleNano today2022

Could artificial intelligence revolutionize the development of nanovectors for gene therapy and mRNA vaccines?

Akbar Hasanzadeh, Michael R Hamblin, Jafar Kiani, Hamid Noori, Joseph M Hardie, Mahdi Karimi, Hadi Shafiee

Open access · greenAbstract read
In one paragraph

Article in Nano today, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 3 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 60 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Akbar HasanzadehCellular and Molecular Research Center, Iran University of Medical Sciences, Tehran 1449614535, Iran.
Michael R HamblinLaser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein 2028, South Africa.
Jafar KianiOncopathology Research Center, Iran University of Medical Sciences, Tehran 1449614535, Iran.
Hamid NooriCellular and Molecular Research Center, Iran University of Medical Sciences, Tehran 1449614535, Iran.
Joseph M HardieDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02139 USA.
Mahdi KarimiCellular and Molecular Research Center, Iran University of Medical Sciences, Tehran 1449614535, Iran.
Hadi ShafieeDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02139 USA.
Iran University of Medical Sciences · IRBrigham and Women's Hospital · USUniversity of Johannesburg · ZA

Funding

Photodynamic Therapy of Localized InfectionsR01AI050875 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HAMBLIN, MICHAEL R · 2003 to 2017
$4.8M
A smartphone-enabled point-of-care HCV Ag diagnostic using catalytic nanoparticles and AI-enhanced image processingR01EB033866 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI SHAFIEE, HADI · 2022 to 2025
$3.3M
Microchip for HBV testing using HIV-infected blood samplesR01AI138800 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI SHAFIEE, HADI · 2019 to 2023
$3.1M
A mobile health diagnostic device for HIV self-testingR33AI140489 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI SHAFIEE, HADI · 2022 to 2023
$1.8M
A mobile health diagnostic device for HIV self-testingR61AI140489 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI SHAFIEE, HADI · 2019 to 2021
$1.6M
Synergistic Photodynamic Therapy for Catherer-Associated Urinary Tract InfectionsR21AI121700 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HAMBLIN, MICHAEL R · 2016 to 2017
$462k
NIAID NIH HHS R01 AI050875NIAID NIH HHS R01 AI138800NIAID NIH HHS R21 AI121700NIAID NIH HHS R33 AI140489NIAID NIH HHS R61 AI140489NIBIB NIH HHS R01 EB033866
6 · The paper itself

Abstract

Gene therapy enables the introduction of nucleic acids like DNA and RNA into host cells, and is expected to revolutionize the treatment of a wide range of diseases. This growth has been further accelerated by the discovery of CRISPR/Cas technology, which allows accurate genomic editing in a broad range of cells and organisms

Indexed as

AICRISPR/Casgene delivery vehiclesgene therapymRNA vaccine carriersnanobots

Identifiers

PMID37034382
PMCPMC10081506
OpenAlexW4308374489

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.