Evidence map›Paper›PMID 37034287›Full record

ArticleJACC. Basic to translational science2023

Immune Profiling Reveals Decreases in Circulating Regulatory and Exhausted T Cells in Human Hypertension.

Matthew R Alexander, Bethany L Dale, Charles D Smart, Fernando Elijovich, Cara E Wogsland, Sierra M Lima, Jonathan M Irish, Meena S Madhur

Open access · goldAbstract read
In one paragraph

Article in JACC. Basic to translational science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Unveiling the Immune Mechanisms of Hypertension With Single-Cell Transcriptome-Wide Mendelian Randomization.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  3. Article
  4. Article
  5. Correlation of Hypertension With Adverse Outcomes Following Total Hip Arthroplasty: A Matched Cohort Analysis.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026
    Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Immune system activation and cognitive impairment in arterial hypertension.American journal of physiology. Cell physiology · 2024
    Review
  13. The role of T cells in vascular aging, hypertension, and atherosclerosis.American journal of physiology. Heart and circulatory physiology · 2024
    Review
  14. Review
  15. Review
  16. Immune and inflammatory mechanisms in hypertension.Nature reviews. Cardiology · 2024
    Review
  17. Article
  18. Article
  19. Article
  20. The immunology of heart failure with preserved ejection fraction.Clinical science (London, England : 1979) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Matthew R AlexanderDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Bethany L DaleDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Charles D SmartDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA.
Fernando ElijovichDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Cara E WogslandDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Sierra M LimaDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Jonathan M IrishVanderbilt Institute for Infection, Immunology, and Inflammation, Nashville, Tennessee, USA.
Meena S MadhurDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Vanderbilt University · USHelsinn Therapeutics (United States) · USVanderbilt University Medical Center · US

Funding

The Role of CCR10+ Regulatory T Cells In HypertensionK08HL153786 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ALEXANDER, MATTHEW R · 2020 to 2024
$792k
Interleukin-21 and endothelial dysfunction in hypertensionF30HL151069 · NHLBI · VANDERBILT UNIVERSITY · PI SMART, CHARLES DUNCAN · 2020 to 2023
$140k
NHLBI NIH HHS F30 HL151069NHLBI NIH HHS K08 HL153786
6 · The paper itself

Abstract

Evidence from nonhuman animal models demonstrates an important role for immune cells in hypertension, but immune cell changes in human hypertension are less clear. Using mass cytometry, we demonstrate novel and selective reductions in CCR10

Indexed as

hypertensionimmunityinflammationlymphocytesmass cytometry

Identifiers

PMID37034287
PMCPMC10077123
OpenAlexW4313598171

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.