Evidence map›Paper›PMID 37034180›Full record

ArticleAddiction neuroscience2023

Towards neuromarkers for tailored smoking cessation treatments.

Francesco Versace, Jason D Robinson, Paul M Cinciripini

Open access · goldAbstract read
In one paragraph

Article in Addiction neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
  2. Article
  3. Addiction biology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. EEG might be better left alone, but ERPs must be attended to: Optimizing the late positive potential preprocessing pipeline.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2024
    Article
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Francesco VersaceDepartment of Behavioral Science, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Jason D RobinsonDepartment of Behavioral Science, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Paul M CinciripiniDepartment of Behavioral Science, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
The University of Texas MD Anderson Cancer Center · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DIANE BODURKA · 1985 to 2026
$290.8M
Pharmacogenetics, Emotional Reactivity &Smoking(RMI)R01DA017073 · NIDA · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI CINCIRIPINI, PAUL MICHAEL · 2004 to 2009
$3.0M
Effectiveness of Varenicline vs. Varenicline plus Bupropion for Smoking CessationR01DA024709 · NIDA · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI CINCIRIPINI, PAUL MICHAEL · 2009 to 2014
$2.9M
Incentive salience and the neuropsychological underpinnings of cue-induced smoking relapseR01DA032581 · NIDA · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI VERSACE, FRANCESCO · 2012 to 2024
$2.5M
NCI NIH HHS P30 CA016672NIDA NIH HHS R01 DA017073NIDA NIH HHS R01 DA024709NIDA NIH HHS R01 DA032581
6 · The paper itself

Abstract

Vulnerability to compulsive drug use stems from dysregulated activity within the neural networks that underlie reward and executive functions. Empirical evidence suggests that a) attributing high motivational salience to drug-related stimuli leads to compulsive drug seeking and b) cognitive control deficits lead to compulsive drug taking. Noninvasive neuroimaging techniques enable brain activity monitoring during affective and cognitive processing and are paving the way to precision medicine for substance use disorders. Identifying robust neuromarkers of affective and cognitive dysregulation would allow clinicians to personalize treatments by targeting individual psychophysiological vulnerabilities. However, methodological choices have biased the field toward experimental paradigms that cannot optimally assess individual differences in the motivational salience of drug-related cues and in the ability to control drug-related decisions, choices which have hindered the identification of clinically relevant neuromarkers. Here, we show that once these shortcomings are amended, replicable neuromarkers of the tendency to attribute motivational salience to drug-related cues and the ability to control drug-related decisions emerge. While we use tobacco use disorder as a model, we also show that the methodological issues highlighted here are relevant to other disorders characterized by maladaptive appetitive behaviors.

Indexed as

BiomarkersCognitive ControlDrug Self-AdministrationEvent-Related PotentialMotivational Salience

Identifiers

PMID37034180
PMCPMC10081511
OpenAlexW4320717311

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.