Evidence map›Paper›PMID 37034151›Full record

ReviewFrontiers in allergy2023

Advances and potential of omics studies for understanding the development of food allergy.

Sayantani B Sindher, Andrew R Chin, Nima Aghaeepour, Lawrence Prince, Holden Maecker, Gary M Shaw, David K Stevenson, Kari C Nadeau, Michael Snyder, Purvesh Khatri and 4 more

Erratum issuedAbstract readReview
In one paragraph

Review in Frontiers in allergy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Immunomodulatory metabolites in IgE-mediated food allergy and oral immunotherapy outcomes based on metabolomic profiling.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2024
    Article
  4. Review
  5. Review
  6. Review
  7. Food Safety-Transcriptomics and Proteomics.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Sayantani B SindherSean N. Parker Center for Allergy and Asthma Research at Stanford University, Palo Alto, CA, United States.
Andrew R ChinSean N. Parker Center for Allergy and Asthma Research at Stanford University, Palo Alto, CA, United States.
Nima AghaeepourDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Palo Alto, CA, United States.
Lawrence PrinceDepartment of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, United States.
Holden MaeckerDepartment of Medicine, Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Palo Alto, CA, United States.
Gary M ShawDepartment of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, United States.
David K StevensonDepartment of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, United States.
Kari C NadeauSean N. Parker Center for Allergy and Asthma Research at Stanford University, Palo Alto, CA, United States.
Michael SnyderDepartment of Genetics, Stanford University, Palo Alto, CA, United States.
Purvesh KhatriDepartment of Medicine, Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Palo Alto, CA, United States.
Scott D BoydSean N. Parker Center for Allergy and Asthma Research at Stanford University, Palo Alto, CA, United States.
Virginia D WinnDepartment of Obstetrics and Gynecology, Stanford University School of Medicine, Palo Alto, CA, United States.
Martin S AngstDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Palo Alto, CA, United States.
R Sharon ChinthrajahSean N. Parker Center for Allergy and Asthma Research at Stanford University, Palo Alto, CA, United States.

Funding

Tracking allergen specific T cells in multi-food allergyU19AI104209 · NIAID · STANFORD UNIVERSITY · PI GALLI, STEPHEN JOSEPH · 2013 to 2025
$17.3M
Machine Learning for Integrative Modeling of the Immune System in Clinical SettingsR35GM138353 · NIGMS · STANFORD UNIVERSITY · PI AGHAEEPOUR, NIMA · 2020 to 2024
$2.2M
Evaluating the role of allergen dose and duration in the safety and efficacy of multi-allergen oral immunotherapy with OmalizumabUM1AI130839 · NIAID · STANFORD UNIVERSITY · PI CHINTHRAJAH, R. SHARON · 2017 to 2023
$1.6M
NIAID NIH HHS U19 AI104209NIAID NIH HHS UM1 AI130839NIGMS NIH HHS R35 GM138353
6 · The paper itself

Abstract

The prevalence of food allergy continues to rise globally, carrying with it substantial safety, economic, and emotional burdens. Although preventative strategies do exist, the heterogeneity of allergy trajectories and clinical phenotypes has made it difficult to identify patients who would benefit from these strategies. Therefore, further studies investigating the molecular mechanisms that differentiate these trajectories are needed. Large-scale omics studies have identified key insights into the molecular mechanisms for many different diseases, however the application of these technologies to uncover the drivers of food allergy development is in its infancy. Here we review the use of omics approaches in food allergy and highlight key gaps in knowledge for applying these technologies for the characterization of food allergy development.

Indexed as

disease developmentfood allergy (FA)genomicsmetabolomicsproteomicstranscriptomics

Identifiers

PMID37034151
PMCPMC10080041

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.