ArticleAnnals of Indian Academy of Neurology
Disease-Modifying Therapy in Subacute Sclerosing Panencephalitis: An Area of Darkness.
Article in Annals of Indian Academy of Neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Movement Disorders in Patients with Subacute Sclerosing Panencephalitis: A Systematic Review.Movement disorders clinical practice · 2024Pooled it
- The Anti-Vaccine Legacy: Re-Emergence of Subacute Sclerosing Panencephalitis in Children.NeuroSci · 2026Article
- Pharmacological content in the television series "House MD": analysis from a German pharmacologist's perspective.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- How I do it: continuous intraventricular interferon alpha infusion in pediatric patients with subacute sclerosing panencephalitis.Acta neurochirurgica · 2025Article
- Subacute Sclerosing Panencephalitis: Impact on Public Health, Current Insights, and Future Perspectives.Brain and behavior · 2025Review
- The role of presynaptic dopaminergic imaging in acquired neurological conditions affecting basal ganglia: a systematic review.Frontiers in neurology · 2025Review
- Subacute Sclerosing Panencephalitis in a North African Cohort: Findings From the Post-Measles Epidemic Era.Sage open pediatricsArticle
- Earlier Onset of Subacute Sclerosing Panencephalitis in Bangladeshi Children: Insights from a Case Series.Sage open pediatricsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Subacute sclerosing panencephalitis (SSPE) is a neurodegenerative disorder because of the persistence of mutated measles virus in the central nervous system. Till date, no curative therapy has been established for SSPE. Multiple drugs have been tried to modify the disease process but have shown mild to moderate benefit at best. It is also challenging to attribute the relative success of some strategies described in single case reports because of the known phenomenon of spontaneous improvement in 5% of patients with SSPE. Critical gaps in understanding the pathophysiological processes involved exist. Current therapies such as interferon alfa require invasive strategies for administration by the intraventricular or intrathecal route, with varying dosage regimens. Oral therapies such as isoprinosine and ribavirin are expensive and not readily available in resource-constrained settings. Most of the evidence so far favors the use of combinational regimens. In this viewpoint, we critically summarize the current evidence on disease-modifying strategies in the context of our region.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.