SynthesisFrontiers in psychiatry2022
Meta-analysis of structural and functional brain alterations in internet gaming disorder.
Synthesis in Frontiers in psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- A systematic review and coordinate-based meta-analysis of resting-state fMRI in athletes from open and closed skills sports.Scientific reports · 2025Pooled it
- Disrupted Sensory-Motor Network Integrity in Excessive Online Gaming: Insight From Multimodal Morphometric Mapping.Brain and behavior · 2026Article
- Structural and functional anatomy of the superior longitudinal fasciculus: a historical and contemporary narrative review.Anatomical science international · 2026Review
- Maternal Neuroplasticity: Understanding Brain Changes with Perinatal Depression and Anxiety in Women.Current psychiatry reports · 2026Review
- Neurostructural Correlates and Impulsive Mechanisms of Exercise Dependence in Middle-Aged and Elderly Adults: Evidence from Gray Matter and Structural Covariance Networks.Brain topography · 2026Article
- BDNF and GSK-3β signaling in depression: molecular mechanisms underlying neural plasticity dysfunction.Molecular biology reports · 2026Review
- Altered Resting-State Functional Connectivity in Internet Gaming Disorder: Convergent Evidence and Independent Validation.Addictive behaviors reports · 2026Article
- Physical exercise moderates the mediating effect of sleep quality between internet addiction and college students' academic burnout.Scientific reports · 2026Article
- Non-linear association between cyberbullying victimization and Internet addiction in Chinese adolescents: a cross-sectional study.BMC public health · 2026Article
- Radiomics-based feature exploration and auxiliary diagnostic model construction for gaming disorder.Scientific reports · 2026Article
- Fifteen years on: a review of the Cam-CAN study of the cognitive neuroscience of ageing.GeroScience · 2026Review
- Atypical cortical neural activity in internet gaming disorder comorbid with autism spectrum disorder during a cue reactivity task: A magnetoencephalography study.PCN reports : psychiatry and clinical neurosciences · 2026Article
- Altered long-range visual hierarchical connectivity in internet gaming disorder: reduced V1-LOC connectivity and its association with addiction severity.Frontiers in psychiatry · 2026Article
- Gaming disorder: Neural mechanisms and ongoing debates.Journal of behavioral addictions · 2025Review
- High-dimensional Metaverse Platforms and the Virtually Extended Self.Journal of cognition · 2024Article
- Trends in use of attention deficit hyperactivity disorder medication among children and adolescents in Scandinavia in 2010-2020.European child & adolescent psychiatry · 2023Article
- Article
- Distinct value-modulated connectomic signatures during monetary incentive anticipation predict severity and craving in internet gaming disorder.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Many neuroimaging studies have reported abnormalities in brain structure and function in internet gaming disorder (IGD). However, the findings were divergent. We aimed to provide evidence-based evidence of structural and functional changes in IGD by conducting a meta-analysis integrating these studies quantitatively. Method: A systematic search was conducted in PubMed, ScienceDirect, Web of Science, and Scopus from January 1, 2010 to October 31, 2021, to identify eligible voxel-based morphometry (VBM) and functional magnetic resonance imaging (fMRI) studies. Brain alternations between IGD subjects and healthy controls (HCs) were compared using the anisotropic seed-based d mapping (AES-SDM) meta-analytic method. Meta-regression analysis was used to investigate the relationship between gray matter volume (GMV) alterations and addiction-related clinical features. Results: The meta-analysis contained 15 VBM studies (422 IGD patients and 354 HCs) and 30 task-state fMRI studies (617 IGD patients and 550 HCs). Compared with HCs, IGD subjects showed: (1) reduced GMV in the bilateral anterior/median cingulate cortex, superior/inferior frontal gyrus and supplementary motor area; (2) hyperactivation in the bilateral inferior frontal gyrus, precentral gyrus, left precuneus, right inferior temporal gyrus and right fusiform; (3) hypoactivation in the bilateral lingual and the left middle frontal gyrus; and (4) both decreased GMV and increased activation in the left anterior cingulate. Furthermore, Meta-regression revealed that GMV reduction in left anterior cingulate were positively correlated with BIS-11 score [ Conclusion: This meta-analysis showed structural and functional impairments in brain regions related to executive control, cognitive function and reward-based decision making in IGD. Furthermore, multi-domain assessments captured different aspects of neuronal changes in IGD, which may help develop effective interventions as potential therapeutic targets.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.