Evidence map›Paper›PMID 37033807›Full record

ArticleACS omega2023

Discovery of Core-Fucosylated Glycopeptides as Diagnostic Biomarkers for Early HCC in Patients with NASH Cirrhosis Using LC-HCD-PRM-MS/MS.

Yifei Tan, Jianhui Zhu, Cristian D Gutierrez Reyes, Yu Lin, Zhijing Tan, Zuowei Wu, Jie Zhang, Alva Cano, Sara Verschleisser, Yehia Mechref and 3 more

Open access · goldAbstract read
In one paragraph

Article in ACS omega, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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  4. The role ofActa pharmaceutica Sinica. B · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Yifei TanDepartment of Liver Surgery, Liver Transplantation Center, West China Hospital of Sichuan University, Chengdu 610017, China.
Jianhui ZhuDepartment of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan 48109, United States.ORCID https://orcid.org/0000-0002-0051-7777
Cristian D Gutierrez ReyesDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409, United States.
Yu LinDepartment of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan 48109, United States.
Zhijing TanDepartment of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan 48109, United States.ORCID https://orcid.org/0000-0003-3618-5388
Zuowei WuDepartment of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan 48109, United States.
Jie ZhangDepartment of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan 48109, United States.
Alva CanoDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.
Sara VerschleisserDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.
Yehia MechrefDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409, United States.ORCID https://orcid.org/0000-0002-6661-6073
Amit G SingalDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.
Neehar D ParikhDepartment of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, United States.
David M LubmanDepartment of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan 48109, United States.ORCID https://orcid.org/0000-0001-7731-0232
University of Michigan · USThe University of Texas Southwestern Medical Center · USTexas Tech University · USSichuan University · CN

Funding

Supplemental for Detection of Glycopeptides of MCI in Patient SerumR01CA160254 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI David M. Lubman · 2012 to 2026
$5.4M
Clinical Validation Center for Hepatocellular CarcinomaU01CA271887 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI FASIHA KANWAL, JORGE A MARRERO · 2022 to 2026
$4.7M
Precision Risk Stratification and Screening for HCC among Patients with Cirrhosis in the United StatesU01CA230694 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI SINGAL, AMIT · 2018 to 2022
$3.5M
NOVEL STRATEGIES TO IMPROVE LIVER CANCER SURVEILLANCE UPTAKE AND EARLY DETECTIONU01CA230669 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LOK, ANNA S.F., SU, GRACE L. · 2018 to 2022
$3.3M
Sensitive and Quantitative MS-bases Glycomic Mapping PlatformR01GM112490 · NIGMS · TEXAS TECH UNIVERSITY · PI MECHREF, YEHIA · 2014 to 2024
$3.2M
Quantitative Characterization of Glycopeptide IsomersR01GM130091 · NIGMS · TEXAS TECH UNIVERSITY · PI Yehia Mechref · 2019 to 2026
$2.5M
Screening of Glycan Markers in Serum for Early Detection of HCC in Different Etiologies of DiseaseU01CA225753 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUBMAN, DAVID M., MECHREF, YEHIA · 2018 to 2021
$2.0M
Orbitrap Fusion Lumos ETD with IRMPD for UM Chemistry MS Facility ExpansionS10OD021619 · OD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAKANSSON, KRISTINA · 2016 to 2016
$1.1M
Discovery and Validation of Biomarkers for Early Cancer Detection Using Mass SpectrometryR50CA221808 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZHU, JIANHUI · 2018 to 2020
$189k
NCI NIH HHS R01 CA160254NCI NIH HHS R50 CA221808NCI NIH HHS U01 CA225753NCI NIH HHS U01 CA230669NCI NIH HHS U01 CA230694NCI NIH HHS U01 CA271887NIGMS NIH HHS R01 GM112490NIGMS NIH HHS R01 GM130091NIH HHS S10 OD021619
6 · The paper itself

Abstract

Aberrant changes in site-specific core fucosylation (CF) of serum proteins contribute to cancer development and progression, which enables them as potential diagnostic markers of tumors. An optimized data-dependent acquisition (DDA) workflow involving isobaric tags for relative and absolute quantitation-labeling and enrichment of CF peptides by lens culinaris lectin was applied to identify CF of serum proteins in a test set of patients with nonalcoholic steatohepatitis (NASH)-related cirrhosis (

Identifiers

PMID37033807
PMCPMC10077536
OpenAlexW4328052364

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.