Evidence map›Paper›PMID 37033737›Full record

ArticleCurrent research in food science2023

Ginsenoside Rd attenuated hyperglycemia via Akt pathway and modulated gut microbiota in streptozotocin-induced diabetic rats.

Wei Wang, Fengtao Guan, Gianni Sagratini, Jie Yan, Jiahan Xie, Zhibo Jin, Meihong Liu, Huimin Liu, Jingsheng Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current research in food science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Wei WangCollege of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin, 130118, China.
Fengtao GuanCollege of Life Science, Jilin Agricultural University, Changchun, Jilin, 130118, China.
Gianni SagratiniSchool of Pharmacy, University of Camerino, Camerino, 62032, Italy.
Jie YanCollege of Life Science, Jilin Agricultural University, Changchun, Jilin, 130118, China.
Jiahan XieCollege of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin, 130118, China.
Zhibo JinCollege of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin, 130118, China.
Meihong LiuCollege of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin, 130118, China.
Huimin LiuCollege of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin, 130118, China.
Jingsheng LiuCollege of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin, 130118, China.
National Engineering Research Center for Wheat · CNJilin Agricultural University · CNUniversità di Camerino · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ginsenoside Rd is a protopanaxadiol abundant in Panax ginseng and Panax notoginseng. It has been reported that ginsenoside Rd possesses various health benefits, such as anti-diabetic, anti-tumor and anti-inflammatory. This work explored the effects of ginsenoside Rd on hyperglycemia and gut microbiota in streptozotocin-induced diabetic rats. Results showed that 5-week ginsenoside Rd (20 mg/kg) treatment significantly improved hyperglycemia in diabetic rats. Besides, ginsenoside Rd promoted glycogen synthesis via activating Akt pathway. It also inhibited hepatic gluconeogenesis, which was associated with inhibiting phosphoenolpyruvate carboxykinase and glucose-6-phosphatase. We further found that ginsenoside Rd treatment increased the diversity of gut microbiota, increased the abundance of beneficial bacteria, such as

Indexed as

Akt pathwayAnti-diabeticGinsenoside RdGut microbiota

Identifiers

PMID37033737
PMCPMC10074500
OpenAlexW4328053268

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.