Evidence map›Paper›PMID 37033682›Full record

ArticleWorld journal of cardiology2023

Prediction of permanent pacemaker implantation after transcatheter aortic valve replacement: The role of machine learning.

Pradyumna Agasthi, Hasan Ashraf, Sai Harika Pujari, Marlene Girardo, Andrew Tseng, Farouk Mookadam, Nithin Venepally, Matthew R Buras, Bishoy Abraham, Banveet K Khetarpal and 9 more

Abstract read
In one paragraph

Article in World journal of cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Clinical Applications of Artificial Intelligence in Structural Heart Disease.Journal of the Society for Cardiovascular Angiography & Interventions · 2026
    Review
  5. Article
  6. Article
  7. Review
  8. Harnessing Artificial Intelligence for Innovation in Interventional Cardiovascular Care.Journal of the Society for Cardiovascular Angiography & Interventions · 2025
    Review
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Pradyumna AgasthiDepartment of Cardiology, Mayo Clinic, Phoenix, AZ 85054, United States.
Hasan AshrafDepartment of Cardiology, Mayo Clinic, Phoenix, AZ 85054, United States.
Sai Harika PujariDepartment of Internal Medicine, The Brooklyn Hospital Center, Brooklyn, NY 11201, United States. spujari@tbh.org.
Marlene GirardoDepartment of Biostatistics, Mayo Clinic, Phoenix, AZ 85054, United States.
Andrew TsengDepartment of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, United States.
Farouk MookadamDepartment of Cardiology, Mayo Clinic, Phoenix, AZ 85054, United States.
Nithin VenepallyDepartment of Cardiology, Mayo Clinic, Phoenix, AZ 85054, United States.
Matthew R BurasDepartment of Statistics, Mayo Clinic, Phoenix, AZ 85054, United States.
Bishoy AbrahamDepartment of Cardiology, Mayo Clinic, Phoenix, AZ 85054, United States.
Banveet K KhetarpalDepartment of Cardiology, Mayo Clinic, Phoenix, AZ 85054, United States.
Mohamed AllamDepartment of Cardiology, Mayo Clinic, Phoenix, AZ 85054, United States.
Siva K Mulpuru MdDepartment of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, United States.
Mackram F EleidDepartment of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, United States.
Kevin L GreasonDepartment of Cardiovascular Surgery, Mayo Clinic, Rochester, MN 55905, United States.
Nirat BeoharMount Sinai Medical Center, Columbia University, Miami Beach, FL 33138, United States.
John SweeneyDepartment of Cardiology, Mayo Clinic, Phoenix, AZ 85054, United States.
David FortuinDepartment of Cardiology, Mayo Clinic, Phoenix, AZ 85054, United States.
David R Jr HolmesDepartment of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, United States.
Reza ArsanjaniDepartment of Cardiology, Mayo Clinic, Phoenix, AZ 85054, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAtrioventricular block requiring permanent pacemaker (PPM) implantation is an important complication of transcatheter aortic valve replacement (TAVR). Application of machine learning could potentially be used to predict pre-procedural risk for PPM.

aimTo apply machine learning to be used to predict pre-procedural risk for PPM.

methodsA retrospective study of 1200 patients who underwent TAVR (January 2014-December 2017) was performed. 964 patients without prior PPM were included for a 30-d analysis and 657 patients without PPM requirement through 30 d were included for a 1-year analysis. After the exclusion of variables with near-zero variance or ≥ 50% missing data, 167 variables were included in the random forest gradient boosting algorithm (GBM) optimized using 5-fold cross-validations repeated 10 times. The receiver operator curve (ROC) for the GBM model and PPM risk score models were calculated to predict the risk of PPM at 30 d and 1 year.

resultsOf 964 patients included in the 30-d analysis without prior PPM, 19.6% required PPM post-TAVR. The mean age of patients was 80.9 ± 8.7 years. 42.1 % were female. Of 657 patients included in the 1-year analysis, the mean age of the patients was 80.7 ± 8.2. Of those, 42.6% of patients were female and 26.7% required PPM at 1-year post-TAVR. The area under ROC to predict 30-d and 1-year risk of PPM for the GBM model (0.66 and 0.72) was superior to that of the PPM risk score (0.55 and 0.54) with a

conclusionThe GBM model has good discrimination and calibration in identifying patients at high risk of PPM post-TAVR.

Indexed as

Machine learningPermanent pacemaker implantationTranscatheter aortic valve replacement

Identifiers

PMID37033682
PMCPMC10074998

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.