ArticleInnovation in aging2023
Subtle Pathophysiological Changes in Working Memory-Related Potentials and Intrinsic Theta Power in Community-Dwelling Older Adults With Subjective Cognitive Decline.
Article in Innovation in aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- The Importance of Subjective Cognitive Decline Recognition and the Potential of Molecular and Neurophysiological Biomarkers-A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Rehabilitation After Severe Traumatic Brain Injury with Acute Symptomatic Seizure: Neurofeedback and Motor Therapy in a 6-Month Follow-Up Case Study.Neurology international · 2026Article
- Memory Test Performance of People with Subjective Cognitive Decline Recruited From Different Settings: A Systematic Review and Meta-analysis.Neuropsychology review · 2025Review
- Neurofeedback-Enhanced Working Memory Training: A Proof-of-Concept for Reversing Age-Related Neural Slowing in Older Adults.medRxiv : the preprint server for health sciences · 2025Article
- Differential Speed and Accuracy Trade-Off in Working Memory Retrieval and Bilateral Precuneus Between Older Men and Women.Brain and behavior · 2025Article
- Cognitive Performance Among Older Adults with Subjective Cognitive Decline.Geriatrics (Basel, Switzerland) · 2025Article
- Differentiation between Normal Cognition and Subjective Cognitive Decline in Older Adults Using Discrepancy Scores Derived from Neuropsychological Tests.Geriatrics (Basel, Switzerland) · 2024Article
- Subjective Cognitive Impairment Can Be Detected from the Decline of Complex Cognition: Findings from the Examination of Remedes 4 Alzheimer's (R4Alz) Structural Validity.Brain sciences · 2024Article
- The aging trajectories of brain functional hierarchy and its impact on cognition across the adult lifespan.Frontiers in aging neuroscience · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Background and Objectives: Individuals with subjective cognitive decline (SCD) who perform normally on objective cognitive tests may have an increased risk of pathological cognitive decline and progression to Alzheimer's disease (AD) and related dementia (ADRD). Working memory is widely regarded as an early sign of pathological cognitive decline. We tested the hypothesis that older adults with SCD already exhibit aberrant neurocognitive processing underlying working memory. Research Design and Methods: Electroencephalography (EEG) was recorded during a delayed match-to-sample (DMS) task and an eyes-closed resting condition in cognitively healthy community-dwelling older adults who were assigned to the SCD or Control group. Results: The SCD and Control groups showed comparable performance on the neuropsychological tests and DMS task. The SCD group showed an enhanced right frontal target-related P300 effect during working memory retrieval and higher frontal theta power during rest. Higher theta power was associated with worse working memory performance and greater left frontal nontarget-related positivity across all older adults. Discussion and Implications: Our findings suggest that older people with SCD have subtle pathophysiological changes in working memory-related potentials and intrinsic theta power, which has important implications for predicting risks and early interventions in older adults in the preclinical stage of ADRD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.