Evidence map›Paper›PMID 37033474›Full record

ArticleFrontiers in cellular and infection microbiology2023

Refractile bodies of

Alana Burrell, Virginia Marugan-Hernandez, Karolin Graefin Von Der Recke, Kelsilandia Aguiar-Martins, Heloisa Berti Gabriel, Fiona M Tomley, Sue Vaughan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Alana BurrellDepartment of Biological and Medical Sciences, Oxford Brookes University, Oxford, United Kingdom.
Virginia Marugan-HernandezDepartment of Pathobiology and Population Sciences, The Royal Veterinary College, University of London, North Mymms, United Kingdom.
Karolin Graefin Von Der ReckeDepartment of Pathobiology and Population Sciences, The Royal Veterinary College, University of London, North Mymms, United Kingdom.
Kelsilandia Aguiar-MartinsDepartment of Pathobiology and Population Sciences, The Royal Veterinary College, University of London, North Mymms, United Kingdom.
Heloisa Berti GabrielDepartment of Biological and Medical Sciences, Oxford Brookes University, Oxford, United Kingdom.
Fiona M TomleyDepartment of Pathobiology and Population Sciences, The Royal Veterinary College, University of London, North Mymms, United Kingdom.
Sue VaughanDepartment of Biological and Medical Sciences, Oxford Brookes University, Oxford, United Kingdom.
University of London · GBOxford Brookes University · GBRoyal Veterinary College · GB

Funding

Biotechnology and Biological Sciences Research Council BB/L002477/1
6 · The paper itself

Abstract

Introduction: Refractile bodies (RB) are large membrane-less organelles (MLO) of unknown function found as a prominent mismatched pair within the sporozoite stages of all species of Methods: High resolution imaging methods including time-lapse live confocal microscopy and serial block face-scanning electron microscopy (SBF-SEM) were used to investigate the morphology of RB and other intracellular organelles before and after sporozoite invasion of host cells. Results: Live cell imaging of MDBK cells infected with Discussion: MLOs in eukaryotic organisms are characterised by their lack of a membrane and ability to undergo liquid-liquid phase separation (LLPS) and fusion, usually in an actin-mediated fashion. Based on the changes in sporozoite cell shape observed at the time of RB merger together with a potential role for actin in this process, we propose that RB are classed as an MLO and recognised as one of the largest MLOs so far characterised.

Indexed as

ChickensCoccidiosisEimeria tenellaOrganellesPoultry DiseasesSporozoitesActinsAnimalsActinsactin dynamicsEimeria tenellaendogenous developmentproteinaceous membrane-less organellesrefractile bodiesSBF-SEM

Identifiers

PMID37033474
PMCPMC10081493
OpenAlexW4323665424

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.