Evidence map›Paper›PMID 37033268›Full record

ArticleFrontiers in endocrinology2023

Exposure to PCB126 during the nursing period reversibly impacts early-life glucose tolerance.

Brittany B Rice, Keegan W Sammons, Sara Y Ngo Tenlep, Madeline T Weltzer, Leryn J Reynolds, Cetewayo S Rashid, Hollie I Swanson, Kevin J Pearson

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Endocrine Disrupting Agents: Toxicological Aspects on Male Reproduction.Reproductive sciences (Thousand Oaks, Calif.) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Brittany B RiceDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, United States.
Keegan W SammonsDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, United States.
Sara Y Ngo TenlepDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, United States.
Madeline T WeltzerDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, United States.
Leryn J ReynoldsHuman Movement Sciences, Darden College of Education, Old Dominion University, Norfolk, VA, United States.
Cetewayo S RashidDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, United States.
Hollie I SwansonDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, United States.
Kevin J PearsonDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, United States.
University of Kentucky · USOld Dominion University · US

Funding

Vascular Mechanisms of PCB-Induced Brain MetastasesP42ES007380 · NIEHS · UNIVERSITY OF KENTUCKY · PI PENNELL, KELLY G · 1997 to 2024
$47.8M
The role of IKKß in linking obesity to adipose tissue inflammation and adipogeneP20GM103527 · NIGMS · UNIVERSITY OF KENTUCKY · PI MORRIS, ANDREW J · 2012 to 2017
$13.7M
Pilot Projects ProgramP30GM127211 · NIGMS · UNIVERSITY OF KENTUCKY · PI CASSIS, LISA A · 2018 to 2022
$5.7M
Summer Research in Environmental Health SciencesR25ES027684 · NIEHS · UNIVERSITY OF KENTUCKY · PI Kevin Joseph Pearson, Hollie Isabel Swanson · 2017 to 2026
$903k
NIEHS NIH HHS P42 ES007380NIEHS NIH HHS R25 ES027684NIGMS NIH HHS P20 GM103527NIGMS NIH HHS P30 GM127211
6 · The paper itself

Abstract

Polychlorinated biphenyls (PCBs) are persistent environmental organic pollutants known to have detrimental health effects. Using a mouse model, we previously demonstrated that PCB126 exposure before and during pregnancy and throughout the perinatal period adversely affected offspring glucose tolerance and/or body composition profiles. The purpose of this study was to investigate the glucose tolerance and body composition of offspring born to dams exposed to PCB126 during the nursing period only. Female ICR mice were bred, and half of the dams were exposed to either vehicle (safflower oil) or 1 µmole PCB126 per kg of body weight

Indexed as

Polychlorinated BiphenylsPrenatal Exposure Delayed EffectsAnimalsBody WeightFemaleGlucoseHumansMaleMiceMice, Inbred ICRPregnancy3,4,5,3',4'-pentachlorobiphenylGlucosePolychlorinated Biphenylsdevelopmental programming of adult diseasediabetesDOHaD (development origins of health and disease)lactationmiceobesitypolychlorinated biophenyls

Identifiers

PMID37033268
PMCPMC10073482
OpenAlexW4353084590

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.