ArticleFrontiers in endocrinology2023
Circulating liver function markers and the risk of COPD in the UK Biobank.
Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Natural products and dietary interventions on liver enzymes: an umbrella review and evidence map.Frontiers in nutrition · 2024Pooled it
- Non-Targeted Metabolomics Profiling and Anti-Inflammatory Potential of Star Anise Extract in Rats with Cold Stress-Aggravated Acute Lung Injury.Metabolites · 2026Article
- Association between cardiovascular-kidney-metabolic syndrome and chronic obstructive pulmonary disease: a cross-national analysis from global, US, and Chinese populations.Respiratory research · 2026Article
- A Novel 10-Protein Score for Liver Fat Content Predicts Cardiovascular-Kidney-Metabolic Disease Risk.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A machine-learning model to identify concurrent vascular disease in symptomatic patients with chronic obstructive pulmonary disease.Annals of medicine · 2025Article
- Body composition mediates the association between fatty acids and NAFLD risk: a prospective cohort study.Journal of health, population, and nutrition · 2025Article
- Associations of prediagnostic serum liver enzyme levels with lung cancer risk in predominantly low-income African and European Americans.Carcinogenesis · 2025Article
- Development and validation a nomogram to predict long-term mortality risks of PRISm and mild-to-moderate COPD based on NHANES 2007-2012.Scientific reports · 2025Article
- Geriatric nutritional risk index as a predictor of mortality in women with chronic inflammatory airway disease: evidence from NHANES 1999-2018.Frontiers in nutrition · 2025Article
- Relationship between lung function impairment, clinical characteristics and systemic inflammation based on a large-scale population screening.Frontiers in medicine · 2025Article
- Association between birth weight and chronic obstructive pulmonary disease in the UK Biobank: a prospective cohort study.BMJ open respiratory research · 2024Article
- Sleep and liver function biomarkers in relation to risk of incident liver cancer: a nationwide prospective cohort study.BMC medicine · 2024Article
- Association and biological pathways between lung function and incident depression: a prospective cohort study of 280,032 participants.BMC medicine · 2024Article
- Association between nutrition-related indicators with the risk of chronic obstructive pulmonary disease and all-cause mortality in the elderly population: evidence from NHANES.Frontiers in nutrition · 2024Article
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To investigate the associations of circulating liver function marker levels with the risk of chronic obstructive pulmonary disease (COPD). Methods: We leveraged the data of 372,056 participants from the UK Biobank between 2006 and 2010. The assessed circulating liver function markers included alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), total bilirubin (TBIL), albumin (ALB), and total protein (TP). Incident COPD was identified through linkage to the National Health Service registries. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Results: During a median follow-up period of 12.3 (interquartile range:11.4-13.2) years, we documented 10,001 newly diagnosed COPD cases. Lower levels of ALT, TBIL, ALB, and TP and higher levels of GGT and ALP were nonlinearly associated with elevated COPD risk. The HR (95% CI) for decile 10 vs. 1 was 0.92 (0.84-1.01) for ALT, 0.82 (0.75-0.89) for TBIL, 0.74 (0.67-0.81) for ALB, 0.96 (0.88-1.04) for TP, 1.45 (1.31-1.62) for GGT, and 1.31 (1.19-1.45) for ALP. Restricted cubic spline analyses suggested a U-shaped relationship between AST levels and COPD risk ( Conclusion: We observed that all seven circulating liver function markers were nonlinearly associated with the risk of COPD, indicating the importance of liver function in COPD.
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