ArticleFrontiers in endocrinology2023
A comprehensive validation study of the latest version of BoneXpert on a large cohort of Caucasian children and adolescents.
Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Real-World Efficacy of Weekly Somatrogon on Growth and Bone Health in Pediatric Growth Hormone Deficiency: A 12-Month Retrospective Cohort StudyJournal of clinical research in pediatric endocrinology · 2026Article
- Growth Hormone Withdrawal in Mid-Puberty: No Impact on Near Adult Height in Adolescents With Transient Idiopathic GHD.The Journal of clinical endocrinology and metabolism · 2026Article
- Bracing AdoleScent Idiopathic Scoliosis after skeletal maturity (BASIS 2): study protocol for a randomized controlled trial within a larger trial.Bone & joint open · 2026Article
- Multidimensional performance characteristics of youth academy and club soccer players.PloS one · 2026Article
- Automated bone age assessment in rare pediatric growth disorders: a comparative study using Deeplasia.Frontiers in endocrinology · 2026Article
- Player ranking is associated with physical performance and body composition in 12-year-old female soccer players.Frontiers in sports and active living · 2026Article
- Integrated cardiac, endocrine, and genetic assessment in adolescent basketball players.Frontiers in endocrinology · 2026Article
- A comparison of two artificial intelligence-based methods for assessing bone age in Turkish children: BoneXpert and VUNO Med-Bone Age.Diagnostic and interventional radiology (Ankara, Turkey) · 2025Article
- Comparative analysis of an automated bone age tool with manual assessment in a multiethnic Southeast Asian paediatric cohort in Singapore.Pediatric radiology · 2025Article
- Population-specific calibration and validation of an open-source bone age AI.Scientific reports · 2025Article
- Comparison of BoneXpert and IB-Lab-PANDA automated Bone Age Evaluation in Children With Growth and Puberty Disorders.Journal of the Endocrine Society · 2025Article
- Associations Between Bone Age, Body Composition and Physical Performance in Icelandic 12-Year-Old Female Soccer Players.European journal of sport science · 2025Article
- A Growth Prediction Model from Mid-Puberty to Near Adult Height in Adolescents with Idiopathic Isolated Growth Hormone Deficiency Treated with Growth Hormone.Hormone research in paediatrics · 2025Article
- Cytogenetic anomalies are the predominant genetic alteration in children with nonfamilial tall stature: a comparative study with familial cases.European journal of pediatrics · 2025Article
- Deep-Learning-based Automated Identification of Ventriculoperitoneal-Shunt Valve Models from Skull X-rays.Clinical neuroradiology · 2025Article
- Retrospective Clinical Trial to Evaluate the Effectiveness of a New Tanner-Whitehouse-Based Bone Age Assessment Algorithm Trained with a Deep Neural Network System.Diagnostics (Basel, Switzerland) · 2025Article
- Comparison of bone age assessment using manual Greulich and Pyle method versus automated BoneXpert method in South African children.SA journal of radiology · 2025Article
- An accurate pediatric bone age prediction model using deep learning and contrast conversion.Ewha medical journal · 2024Article
- Relationships between bone age, physical performance, and motor coordination among adolescent male and female athletes.Frontiers in sports and active living · 2024Article
- The promise and limitations of artificial intelligence in musculoskeletal imaging.Frontiers in radiology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Automated bone age assessment has recently become increasingly popular. The aim of this study was to assess the agreement between automated and manual evaluation of bone age using the method according to Tanner-Whitehouse (TW3) and Greulich-Pyle (GP). Methods: We evaluated 1285 bone age scans from 1202 children (657 scans from 612 boys) by using both manual and automated (TW3 as well as GP) bone age assessment. BoneXpert software versions 2.4.5.1. (BX2) and 3.2.1. (BX3) (Visiana, Holte, Denmark) were compared with manual evaluation using root mean squared error (RMSE) analysis. Results: RMSE for BX2 was 0.57 and 0.55 years in boys and 0.72 and 0.59 years in girls, respectively for TW3 and GP. For BX3, RMSE was 0.51 and 0.68 years in boys and 0.49 and 0.52 years in girls, respectively for TW3 and GP. Sex- and age-specific analysis for BX2 identified the largest differences between manual and automated TW3 evaluation in girls between 6-7, 12-13, 13-14 and 14-15 years, with RMSE 0.88, 0.81, 0.92 and 0.84 years, respectively. The BX3 version showed better agreement with manual TW3 evaluation (RMSE 0.64, 0.45, 0.46 and 0.57). Conclusion: The latest version of the BoneXpert software provides improved and clinically sufficient agreement with manual bone age evaluation in children of both sexes compared to the previous version and may be used for routine bone age evaluation in non-selected cases in pediatric endocrinology care.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.