Evidence map›Paper›PMID 37032887›Full record

ArticleFrontiers in microbiology2023

Characterization of cephalosporin and fluoroquinolone resistant Enterobacterales from Irish farm waste by whole genome sequencing.

Deirdre M Prendergast, Rosemarie Slowey, Catherine M Burgess, Declan Murphy, Dayle Johnston, Dearbháile Morris, Áine O' Doherty, John Moriarty, Montserrat Gutierrez

Abstract read
In one paragraph

Article in Frontiers in microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Phenotypic and Genomic Profiling ofAntibiotics (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Evidence for antimicrobial stewardship and reduced antimicrobial resistance in the Mid-West of Ireland, 2012 to 2023: findings from a One Health study.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025
    Article
  4. Whole genome sequencing analysis of non-O157 Shiga toxin-producingIranian journal of veterinary research · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Deirdre M PrendergastDepartment of Agriculture, Food and the Marine, Celbridge, Co. Kildare, Ireland.
Rosemarie SloweyDepartment of Agriculture, Food and the Marine, Celbridge, Co. Kildare, Ireland.
Catherine M BurgessTeagasc Food Research Centre, Ashtown, Dublin, Ireland.
Declan MurphyDepartment of Agriculture, Food and the Marine, Celbridge, Co. Kildare, Ireland.
Dayle JohnstonDepartment of Agriculture, Food and the Marine, Celbridge, Co. Kildare, Ireland.
Dearbháile MorrisAntimicrobial Resistance and Microbial Ecology Group, University of Galway, Galway, Ireland.
Áine O' DohertyDepartment of Agriculture, Food and the Marine, Celbridge, Co. Kildare, Ireland.
John MoriartyDepartment of Agriculture, Food and the Marine, Celbridge, Co. Kildare, Ireland.
Montserrat GutierrezDepartment of Agriculture, Food and the Marine, Celbridge, Co. Kildare, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The Enterobacterales are a group of Gram-negative bacteria frequently exhibiting extended antimicrobial resistance (AMR) and involved in the transmission of resistance genes to other bacterial species present in the same environment. Due to their impact on human health and the paucity of new antibiotics, the World Health Organization (WHO) categorized carbapenem resistant and ESBL-producing as critical. Enterobacterales are ubiquitous and the role of the environment in the transmission of AMR organisms or antimicrobial resistance genes (ARGs) must be examined in tackling AMR in both humans and animals under the one health approach. Animal manure is recognized as an important source of AMR bacteria entering the environment, in which resistant genes can accumulate. Methods: To gain a better understanding of the dissemination of third generation cephalosporin and fluoroquinolone resistance genes between isolates in the environment, we applied whole genome sequencing (WGS) to Enterobacterales (79 Results: A wide variety of cephalosporin and fluoroquinolone resistance genes (mobile genetic elements (MGEs) and chromosomal mutations) were identified among isolates that mostly explained the phenotypic AMR patterns. A total of 31 plasmid replicon types were identified among the 82 isolates, with a subset of them ( Conclusion: Our study showed that antimicrobial resistant organisms (AROs) can persist even following wastewater treatment and could transmit AMR of clinical relevance to the environment and ultimately pose a risk to human or animal health.

Indexed as

antimicrobial resistancecephalosporinEnterobacteralesenvironmentfluoroquinolonewhole genome sequencing

Identifiers

PMID37032887
PMCPMC10073600

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.