Evidence map›Paper›PMID 37032483›Full record

ArticleJournal of Korean Neurosurgical Society2023

Intrawound Vancomycin Powder Application for Preventing Surgical Site Infection Following Cranioplasty.

Seong Bin Youn, Gyojun Hwang, Hyun-Gon Kim, Jae Seong Kang, Hyung Cheol Kim, Sung Han Oh, Mi-Kyung Kim, Bong Sub Chung, Jong Kook Rhim, Seung Hun Sheen

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Korean Neurosurgical Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07547826 (Efficacy and Cost-Effectiveness of Topical Vancomycin Powder in Preventing Pediatric Ventriculoperitoneal Shunt Infections Across Different Etiologies), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07547826 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Efficacy and Cost-Effectiveness of Topical Vancomycin Powder in Preventing Pediatric Ventriculoperitoneal Shunt Infections Across Different Etiologies

TypeinterventionalSponsorAssiut UniversityRan2026 to 2027Enrolled164ConditionsHydrocephalus, Ventriculoperitoneal Shunt Infection, Surgical Site Infection (SSI), Cerebrospinal Fluid Shunt InfectionArmsTopical Vancomycin Powder, Standard Perioperative Care
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Seong Bin YounDepartment of Neurosurgery, Bundang Jesaeng General Hospital, Daejin Medical Center, Seongnam, Korea.
Gyojun HwangDepartment of Neurosurgery, Bundang Jesaeng General Hospital, Daejin Medical Center, Seongnam, Korea.
Hyun-Gon KimDepartment of Neurosurgery, Bundang Jesaeng General Hospital, Daejin Medical Center, Seongnam, Korea.
Jae Seong KangDepartment of Neurosurgery, Bundang Jesaeng General Hospital, Daejin Medical Center, Seongnam, Korea.
Hyung Cheol KimDepartment of Neurosurgery, Bundang Jesaeng General Hospital, Daejin Medical Center, Seongnam, Korea.
Sung Han OhDepartment of Neurosurgery, Bundang Jesaeng General Hospital, Daejin Medical Center, Seongnam, Korea.
Mi-Kyung KimDepartment of Neurosurgery, Myongji St Mary's Hospital, Seoul, Korea.
Bong Sub ChungDepartment of Neurosurgery, Anyang Sam Hospital, Anyang, Korea.
Jong Kook RhimDepartment of Neurosurgery, Jeju National University Hospital, Jeju, Korea.
Seung Hun SheenDepartment of Neurosurgery, Bundang CHA Medical Center, CHA University, Seongnam, Korea.
Bundang Jesaeng Hospital · KRCHA University Bundang Medical Center · KRJeju National University Hospital · KRYang Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveSurgical site infection is the most detrimental complication following cranioplasty. In other surgical fields, intrawound vancomycin powder application has been introduced to prevent surgical site infection and is widely used based on results in multiple studies. This study evaluated the effect of intrawound vancomycin powder in cranioplasty compared with the conventional method without topical antibiotics.

methodsThis retrospective study included 580 patients with skull defects who underwent cranioplasty between August 1, 1998 and December 31, 2021. The conventional method was used in 475 (81.9%; conventional group) and vancomycin powder (1 g) was applied on the dura mater and bone flap in 105 patients (18.1%; vancomycin powder group). Surgical site infection was defined as infection of the incision, organ, or space that occurred after cranioplasty. Surgical site infection within 1-year surveillance period was compared between the conventional and vancomycin powder groups with logistic regression analysis. Penalized likelihood estimation method was used in logistic regression to deal with zero events. All local and systemic adverse events associated with topical vancomycin application were also evaluated.

resultsSurgical site infection occurred in 31 patients (5.3%) and all were observed in the conventional group. The median time between cranioplasty and detection of surgical site infection was 13 days (range, 4-333). Staphylococci were the most common organisms and identified in 25 (80.6%) of 31 cases with surgical site infections. The surgical site infection rate in the vancomycin powder group (0/105, 0.0%) was significantly lower than that in the conventional group (31/475, 6.5%; crude odds ratio [OR], 0.067; 95% confidence interval [CI], 0.006-0.762; adjusted OR, 0.068; 95% CI, 0.006-0.731; p=0.026). No adverse events associated with intrawound vancomycin powder were observed during the follow-up.

conclusionIntrawound vancomycin powder effectively prevented surgical site infections following cranioplasty without local or systemic adverse events. Our results suggest that intrawound vancomycin powder is an effective and safe strategy for patients undergoing cranioplasty.

Indexed as

CranioplastyPowdersSurgical wound infectionVancomycin

Identifiers

PMID37032483
PMCPMC10483168
OpenAlexW4362735435

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.