Evidence map›Paper›PMID 37032399›Full record

ArticleJournal of endocrinological investigation2023

Effectiveness and safety of the radiofrequency ablation of single hyperfunctioning parathyroid lesions suggestive of adenomas in primary hyperparathyroidism.

S León Utrero, F Garrido-Pareja, P López-Ibarra, M Quesada-Charneco, E López-Mezquita, V Ávila-Rubio, J L Martín-Rodríguez

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In one paragraph

Article in Journal of endocrinological investigation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

S León UtreroDepartment of Endocrinology and Nutrition, University Hospital Clínico San Cecilio, Av. de La Ilustración, s/n, 18016, Granada, Spain.ORCID http://orcid.org/0000-0003-0076-314X
F Garrido-ParejaDepartment of Radiology, University Hospital Clínico San Cecilio, Av. de La Ilustración, s/n, 18016, Granada, Spain.
P López-IbarraDepartment of Endocrinology and Nutrition, University Hospital Clínico San Cecilio, Av. de La Ilustración, s/n, 18016, Granada, Spain.
M Quesada-CharnecoDepartment of Endocrinology and Nutrition, University Hospital Clínico San Cecilio, Av. de La Ilustración, s/n, 18016, Granada, Spain.
E López-MezquitaDepartment of Endocrinology and Nutrition, University Hospital Clínico San Cecilio, Av. de La Ilustración, s/n, 18016, Granada, Spain.
V Ávila-RubioDepartment of Endocrinology and Nutrition, University Hospital Clínico San Cecilio, Av. de La Ilustración, s/n, 18016, Granada, Spain.
J L Martín-RodríguezDepartment of Radiology, University Hospital Clínico San Cecilio, Av. de La Ilustración, s/n, 18016, Granada, Spain.
Instituto de Investigación Biosanitaria de Granada · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionRadiofrequency ablation (RFA) has emerged as a minimally invasive approach to single parathyroid adenoma in primary hyperparathyroidism; however, there is limited evidence on its effectiveness.

objectiveTo evaluate the effectiveness and safety of RFA to treat hyper-functioning parathyroid lesions suggestive of adenomas. MATERIAL AND

methodsA prospective study was conducted in consecutive patients with primary hyperparathyroidism treated with RFA for single parathyroid lesions in our reference center between November 2017 and June 2021. Pre-treatment (baseline) and follow-up analytical data were gathered on total protein-adjusted calcium, parathyroid hormone [PTH], phosphorus, and 24-h urine calcium. Effectiveness was defined as complete response (normal calcium and PTH), partial response (reduced but not normalized PTH with normal serum calcium), or disease persistence (elevated calcium and PTH). SPSS 15.0 was used for statistical analysis.

resultsFour of thirty-three enrolled patients were lost to the follow-up. The final sample comprised 29 patients (22 females) with mean age of 60.93 ± 13.28 years followed up for a mean of 16.29 ± 7.23 months. Complete response was observed in 48.27%, partial response in 37.93%, and hyperparathyroidism persistence in 13.79%. Serum calcium and PTH levels were significantly lower at 1 and 2 years of post-treatment than at baseline. Adverse effects were mild, with two cases of dysphonia (self-limited in one patient) and no cases of hypocalcaemia or hypoparathyroidism.

conclusionRFA may be a safe and effective technique to treat hyper-functioning parathyroid lesions in selected patients.

Indexed as

AdenomaHyperparathyroidism, PrimaryRadiofrequency AblationAgedCalciumFemaleHumansMiddle AgedParathyroid HormoneProspective StudiesCalciumParathyroid HormoneParathyroid adenomasPrimary hyperparathyroidismRadiofrequency ablation

Identifiers

PMID37032399
OpenAlexW4362723998

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.