Evidence map›Paper›PMID 37032347›Full record

ArticleJournal of molecular medicine (Berlin, Germany)2023

Melatonin inhibits senescence-associated melanin pigmentation through the p53-TYR pathway in human primary melanocytes and the skin of C57BL/6 J mice after UVB irradiation.

Li-Ping Ma, Meng-Meng Liu, Fang Liu, Bo Sun, Si-Nian Wang, Jie Chen, Hui-Jie Yu, Juan Yan, Mei Tian, Ling Gao and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular medicine (Berlin, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Li-Ping MaChina CDC Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, 100088, Beijing, China.
Meng-Meng LiuChina CDC Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, 100088, Beijing, China.
Fang LiuDepartment of Dermatology, Chaoyang Hospital, Capital Medical University, 100020, Beijing, China.
Bo SunPLA Rocket Force Characteristic Medical Center, 100088, Beijing, China.
Si-Nian WangPLA Rocket Force Characteristic Medical Center, 100088, Beijing, China.
Jie ChenChina CDC Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, 100088, Beijing, China.
Hui-Jie YuPLA Rocket Force Characteristic Medical Center, 100088, Beijing, China.
Juan YanChina CDC Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, 100088, Beijing, China.
Mei TianChina CDC Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, 100088, Beijing, China.
Ling GaoChina CDC Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, 100088, Beijing, China. gaoling@nirp.chinacdc.cn.ORCID 0000-0002-1846-7106
Qing-Jie LiuChina CDC Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, 100088, Beijing, China. liuqingjie@nirp.chinacdc.cn.
Chinese Center For Disease Control and Prevention · CNCapital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

UVB exposure accelerates skin aging and pigmentation. Melatonin effectively regulates tyrosinase (TYR) activity and aging. The purpose of this study was to determine the association between premature senescence and pigmentation, and the mechanism of melanin synthesis effected by melatonin. Primary melanocytes were extracted and identified from the male foreskin. To inhibit TYR expression, primary melanocytes were transduced with the lentivirus pLKD-CMV-EGFP-2A-Puro-U6-TYR. The wild-type TYR

Indexed as

MelaninsMelatoninAnimalsErythemaHumansMaleMelanocytesMiceMice, Inbred C57BLSkin PigmentationTumor Suppressor Protein p53MelaninsMelatoninTumor Suppressor Protein p53MelaninMelanocytesp53Premature senescenceTYRUltraviolet B

Identifiers

PMID37032347
PMCPMC10163137
OpenAlexW4362731340

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.