Evidence map›Paper›PMID 37032081›Full record

ArticleInternal medicine (Tokyo, Japan)2023

Atypical Cogan's Syndrome with Large-vessel Vasculitis Successfully Treated with Tocilizumab.

Misako Higashida-Konishi, Mitsuhiro Akiyama, Hiroki Tabata, Satoshi Hama, Tatsuhiro Oshige, Keisuke Izumi, Hisaji Oshima, Yutaka Okano

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Misako Higashida-KonishiDivision of Rheumatology, Department of Medicine, National Hospital Organization Tokyo Medical Center, Japan.
Mitsuhiro AkiyamaDivision of Rheumatology, Department of Medicine, National Hospital Organization Tokyo Medical Center, Japan.
Hiroki TabataDivision of Rheumatology, Department of Medicine, National Hospital Organization Tokyo Medical Center, Japan.
Satoshi HamaDivision of Rheumatology, Department of Medicine, National Hospital Organization Tokyo Medical Center, Japan.
Tatsuhiro OshigeDivision of Rheumatology, Department of Medicine, National Hospital Organization Tokyo Medical Center, Japan.
Keisuke IzumiDivision of Rheumatology, Department of Medicine, National Hospital Organization Tokyo Medical Center, Japan.
Hisaji OshimaDivision of Rheumatology, Department of Medicine, National Hospital Organization Tokyo Medical Center, Japan.
Yutaka OkanoDivision of Rheumatology, Department of Medicine, National Hospital Organization Tokyo Medical Center, Japan.
Tokyo Medical Center · JPNational Hospital Organization · JPKeio University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 61-year-old man presented with weight loss, bilateral ocular redness, blurred vision, and sensorineural hearing loss. Fluorodeoxyglucose-position emission tomography/computed tomography demonstrated an uptake in the ascending and descending aorta, abdominal aorta and femoral arteries. Atypical Cogan's syndrome complicated with large-vessel vasculitis (LVV) was diagnosed. He was treated with high-dose prednisolone and subcutaneous tocilizumab (162 mg/week), resulting in successful improvements in his ocular and vascular involvements. Although there is currently no established treatment strategy for LVV associated with Cogan's syndrome, our case and literature review suggest that tocilizumab is a viable treatment option for this rare but life-threatening complication.

Indexed as

Cogan SyndromeHearing Loss, SensorineuralAntibodies, Monoclonal, HumanizedApraxiasHumansMaleMiddle AgedAntibodies, Monoclonal, Humanizedtocilizumabanti-interleukin-6 receptor antibodyCogan's syndromeinterleukin-6large vessel vasculitistocilizumab

Identifiers

PMID37032081
PMCPMC10713379
OpenAlexW4362680466

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.