Evidence map›Paper›PMID 37032051›Full record

ArticleAnalytica chimica acta2023

Gold-silver alloy hollow nanoshells-based lateral flow immunoassay for colorimetric, photothermal, and SERS tri-mode detection of SARS-CoV-2 neutralizing antibody.

Tianyu Zhao, Penghui Liang, Jiaqi Ren, Jinyue Zhu, Xianning Yang, Hongyu Bian, Jingwen Li, Xiaofeng Cui, Chunhui Fu, Jinyan Xing and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytica chimica acta, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
6.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 57 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Tianyu ZhaoCollege of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao, 266580, PR China.
Penghui LiangCollege of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao, 266580, PR China.
Jiaqi RenCollege of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao, 266580, PR China.
Jinyue ZhuCollege of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao, 266580, PR China.
Xianning YangCollege of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao, 266580, PR China.
Hongyu BianCollege of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao, 266580, PR China.
Jingwen LiCollege of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao, 266580, PR China.
Xiaofeng CuiQingdao Henderson Biological Technology Co., Ltd, Qingdao, 266109, PR China.
Chunhui FuQingdao Henderson Biological Technology Co., Ltd, Qingdao, 266109, PR China.
Jinyan XingThe Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266003, PR China. Electronic address: xingjy@qdu.edu.cn.
Congying WenCollege of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao, 266580, PR China. Electronic address: flcyxt@163.com.
Jingbin ZengCollege of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao, 266580, PR China. Electronic address: zengjb@upc.edu.cn.
China University of Petroleum, East China · CNAffiliated Hospital of Qingdao University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although many approaches have been developed for the quick assessment of SARS-CoV-2 infection, few of them are devoted to the detection of the neutralizing antibody, which is essential for assessing the effectiveness of vaccines. Herein, we developed a tri-mode lateral flow immunoassay (LFIA) platform based on gold-silver alloy hollow nanoshells (Au-Ag HNSs) for the sensitive and accurate quantification of neutralizing antibodies. By tuning the shell-to-core ratio, the surface plasmon resonance (SPR) absorption band of the Au-Ag HNSs is located within the near infrared (NIR) region, endowing them with an excellent photothermal effect under the irradiation of optical maser at 808 nm. Further, the Raman reporter molecule 4-mercaptobenzoic acid (MBA) was immobilized on the gold-silver alloy nanoshell to obtain an enhanced SERS signal. Thus, these Au-Ag HNSs could provide colorimetric, photothermal and SERS signals, with which, tri-mode strips for SARS-CoV-2 neutralizing antibody detection were constructed by competitive immunoassay. Since these three kinds of signals could complement one another, a more accurate detection was achieved. The tri-mode LFIA achieved a quantitative detection with detection limit of 20 ng/mL. Moreover, it also successfully detected the serum samples from 98 vaccinated volunteers with 79 positive results, exhibiting great application value in neutralizing antibody detection.

Indexed as

Antibodies, NeutralizingCOVID-19ImmunoassayNanoshellsSARS-CoV-2Spectrum Analysis, RamanAlloysAntibodies, ViralColorimetryGoldHumansMetal NanoparticlesSilverAlloysAntibodies, NeutralizingAntibodies, ViralGoldSilverColorimetryLateral flow immunoassayPhotothermal effectsSARS-CoV-2 neutralizing antibodySurface-enhanced Raman scattering

Identifiers

PMID37032051
PMCPMC10026621
OpenAlexW4327918530

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.