Evidence map›Paper›PMID 37031925›Full record

ArticleRespiratory physiology & neurobiology2023

Effects of DNA methylase inhibitors in a murine model of severe BPD.

Kathryn M Heyob, Zahra Khuhro, Aiman Q Khan, Dorian Brown, Trent E Tipple, Lynette K Rogers

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory physiology & neurobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Kathryn M HeyobCenter for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
Zahra KhuhroCenter for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
Aiman Q KhanCenter for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
Dorian BrownCenter for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
Trent E TippleSection of Neonatal-Perinatal Medicine, Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Lynette K RogersCenter for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA; Department of Pediatrics, The Ohio State University, Columbus, OH, USA. Electronic address: Lynette.Rogers@NationwideChildrens.org.
Nationwide Children's Hospital · USUniversity of Oklahoma Health Sciences Center · US

Funding

Optimizing Therapeutic delivery of MicroRNAs to prevent chronic lung disease in Preterm infants.R01HD088033 · NICHD · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI ROGERS, LYNETTE KAY · 2017 to 2021
$1.6M
NICHD NIH HHS R01 HD088033
6 · The paper itself

Abstract

DNA methylation is necessary for developmental gene regulation, but adverse environments result in aberrant methylation and gene silencing. The current pilot study tested the hypothesis that treatment with DNA methylation inhibitors (decitabine; RG108) would improve alveolarization in a newborn murine model of severe bronchopulmonary dysplasia. Newborn mice exposed to maternal inflammation (LPS) and neonatal hyperoxia (85% O

Indexed as

Bronchopulmonary DysplasiaHyperoxiaAnimalsAnimals, NewbornDecitabineDisease Models, AnimalDNALungMicePhthalimidesPilot ProjectsTryptophanDecitabineDNAPhthalimidesRG108TryptophanAlveolarizationdecitabineDNMTRG108TGFβ1

Identifiers

PMID37031925
PMCPMC11736813
OpenAlexW4362696285

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.