Evidence map›Paper›PMID 37031749›Full record

ReviewAdvances in nutrition (Bethesda, Md.)2023

Exploring the Influence of Gut Microbiome on Energy Metabolism in Humans.

Julia Montenegro, Anissa M Armet, Benjamin P Willing, Edward C Deehan, Priscila G Fassini, João F Mota, Jens Walter, Carla M Prado

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advances in nutrition (Bethesda, Md.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.

  1. Effects ofFrontiers in nutrition · 2025
    Pooled it
  2. Trial
  3. Article
  4. A qPCR-based approach targeting the microbial gene markerJournal of Parkinson's disease · 2026
    Article
  5. Clostridium Abundance and Lower Weight-for-AgeJMIR pediatrics and parenting · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Observational
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 4 countries.

Julia MontenegroDepartment of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.
Anissa M ArmetDepartment of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.
Benjamin P WillingDepartment of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.
Edward C DeehanDepartment of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada; Department of Food Science and Technology, University of Nebraska, Lincoln, Nebraska, United States; Nebraska Food for Health Center, University of Nebraska, Lincoln, Nebraska, United States.
Priscila G FassiniDepartment of Internal Medicine, Division of Nutrology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
João F MotaSchool of Nutrition, Federal University of Goiás, Goiânia, Goiás, Brazil; APC Microbiome Ireland, School of Microbiology, and Department of Medicine, University College Cork - National University of Ireland, Cork, Ireland.
Jens WalterDepartment of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada; APC Microbiome Ireland, School of Microbiology, and Department of Medicine, University College Cork - National University of Ireland, Cork, Ireland. Electronic address: jenswalter@ucc.ie.
Carla M PradoDepartment of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada. Electronic address: carla.prado@ualberta.ca.
University of Alberta · CAUniversidade de São Paulo · BRUniversity College Cork · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut microbiome has a profound influence on host physiology, including energy metabolism, which is the process by which energy from nutrients is transformed into other forms of energy to be used by the body. However, mechanistic evidence for how the microbiome influences energy metabolism is derived from animal models. In this narrative review, we included human studies investigating the relationship between gut microbiome and energy metabolism -i.e., energy expenditure in humans and energy harvest by the gut microbiome. Studies have found no consistent gut microbiome patterns associated with energy metabolism, and most interventions were not effective in modulating the gut microbiome to influence energy metabolism. To date, cause-and-effect relationships and mechanistic evidence on the impact of the gut microbiome on energy expenditure have not been established in humans. Future longitudinal observational studies and randomized controlled trials utilizing robust methodologies and advanced statistical analysis are needed. Such knowledge would potentially inform the design of therapeutic avenues and specific dietary recommendations to improve energy metabolism through gut microbiome modulation.

Indexed as

Gastrointestinal MicrobiomeMicrobiotaAnimalsDietEnergy MetabolismHumansNutrientsNutrientsenergy expenditureenergy harvestenergy metabolismGut microbiome

Identifiers

PMID37031749
PMCPMC10334151
OpenAlexW4362696261

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.