Evidence map›Paper›PMID 37031330›Full record

ArticleJournal of bone and mineral metabolism2023

Resveratrol prevents ovariectomy-induced bone quality deterioration by improving the microarchitectural and biophysicochemical properties of bone.

Sevval Ozturk, Ibrahim Cuneyit, Fatih Altuntas, Ege Riza Karagur, Aysegul Cort Donmez, Mert Ocak, Mustafa Unal, Mehmet Sarikanat, Baris Ozgur Donmez

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In one paragraph

Article in Journal of bone and mineral metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Sevval OzturkSchool of Medicine, Department of Anatomy, Pamukkale University, 20070, Denizli, Turkey.
Ibrahim CuneyitSchool of Medicine, Department of Anatomy, Pamukkale University, 20070, Denizli, Turkey.
Fatih AltuntasSchool of Medicine, Department of Physiology, Pamukkale University, 20070, Denizli, Turkey.
Ege Riza KaragurSchool of Medicine, Department of Medical Genetics, Pamukkale University, 20070, Denizli, Turkey.
Aysegul Cort DonmezSchool of Medicine, Department of Medical Biochemistry, Pamukkale University, 20070, Denizli, Turkey.
Mert OcakSchool of Dentistry, Department of Anatomy, Ankara University, 06650, Ankara, Turkey.
Mustafa UnalSchool of Medicine, Department of Biophysics, Karamanoglu Mehmetbey University, 70200, Karaman, Turkey.
Mehmet SarikanatFaculty of Engineering, Department of Mechanical Engineering, Ege University, 35040, Izmir, Turkey.
Baris Ozgur DonmezSchool of Medicine, Department of Anatomy, Pamukkale University, 20070, Denizli, Turkey. bozgurd@pau.edu.tr.
Pamukkale University · TRAnkara University · TREge University · TRKaramanoğlu Mehmetbey University · TR

Funding

Pamukkale Üniversitesi 2021SABE007.
6 · The paper itself

Abstract

introductionOsteoporosis is a major health problem that is very common worldwide and is characterized by both low bone density and deterioration in bone quality. New treatment options without side effects have become an active area of research in recent years. This study was designed to investigate the preventive effects of resveratrol on bone quality deterioration caused by ovariectomy. MATERIALS AND

methodsSixty rats were randomly divided into five groups (12 animals per group): Control, Sham-operated (SHAM), ovariectomized (OVX), OVX + Resveratrol-40 mg/kg/day (OVX + Res40), OVX + Resveratrol-80 mg/kg/day (OVX + Res80). Resveratrol was administered by oral gavage (40 and 80 mg/kg/day) for ten weeks. Micro-CT measurements, biomechanical testing, Raman spectroscopy analysis, and RT-PCR analysis were performed. ALP, OCN, TAS, and TOS levels were also measured from blood serum.

resultsBone strength, bone volume/total volume, trabecular volume, and trabecular thickness were higher in the OVX + RES-80 group than in the OVX group. Resveratrol increased osteogenic differentiation, as the expression of osteogenic markers ALP, Col1A1, Runx2, OPG, OCN increased in both OVX + RES-80 and OVX + RES-40 groups compared to the OVX group. 80 mg/kg/day resveratrol administration decreased the levels of ALP, OCN and TOS in ovariectomized rats. Raman spectroscopy findings showed a preventive effect of resveratrol administration against ovariectomy-induced deterioration in biophysiochemical properties of bone tissue.

conclusionThis study revealed that administration of different doses of 80 mg/kg/day and 40 mg/kg/day of resveratrol had protective effects on bone quality deterioration caused by ovariectomy.

Indexed as

OsteogenesisOsteoporosisAnimalsBone and BonesBone DensityFemaleHumansOvariectomyRatsResveratrolResveratrolBone biologyOsteoporosisOvariectomyRaman spectroscopyResveratrol

Identifiers

PMID37031330
OpenAlexW4362722639

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.