Evidence map›Paper›PMID 37031282›Full record

ArticleClinical and experimental medicine2023

Side effects of COVID-19 vaccinations in patients treated for breast cancer.

Brooke C Juhel, Cheryl L Brunelle, Madison C Bernstein, Louisa H Smith, Amanda W Jung, Hazim S Ababneh, Elizabeth K Hausman, Loryn K Bucci, Tess Bernstein, George E Naoum and 1 more

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04872738 (Patient Experiences With the COVID-19 Vaccination After Breast Cancer Treatment), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04872738 completednot on this map

Patient Experiences With the COVID-19 Vaccination After Breast Cancer Treatment

TypeobservationalSponsorMassachusetts General HospitalRan2021 to 2023Enrolled714ConditionsBreast Cancer Related Lymphedema, Covid19ArmsSurvey
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Side effects of COVID-19 vaccination and breast cancer.Clinical and experimental medicine · 2023
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Brooke C JuhelDepartment of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Cheryl L BrunelleDepartment of Physical and Occupational Therapy, Massachusetts General Hospital, Boston, MA, USA.
Madison C BernsteinDepartment of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Louisa H SmithDepartment of Health Sciences, Bouvé College of Health Sciences, Northeastern University, Boston, MA, USA.
Amanda W JungDepartment of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Hazim S AbabnehDepartment of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Elizabeth K HausmanDepartment of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Loryn K BucciDepartment of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Tess BernsteinDepartment of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
George E NaoumDepartment of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Alphonse G TaghianDepartment of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. ataghian@mgh.harvard.edu.ORCID http://orcid.org/0000-0003-2211-9355
Harvard University · USMassachusetts General Hospital · USNortheastern University · US

Funding

NCI NIH HHS P50CA08393
6 · The paper itself

Abstract

Lymph node swelling is a side effect of the mRNA COVID-19 vaccines, a distressing side effect for women treated for breast cancer. The purpose of this study is to present side effects reported by a cohort of patients treated for breast cancer. A survey link was sent to 4945 women who received breast cancer treatment and were prospectively screened for breast cancer-related lymphedema. In total, 621 patients who received an mRNA vaccine and responded to the survey were included in analysis. We assessed the frequency and predictors of side effects. The most frequent side effects reported were injection site soreness, fatigue, generalized muscle soreness, headache, and chills, with median duration  ≤ 48 h. Lymph node swelling occurred most often in the axilla ipsilateral to the vaccine. The median duration was 1 week or less after all doses. These data will inform patient education regarding future vaccine doses, including reassurances about which side effects to expect, particularly lymph node swelling which may impact mammograms after vaccination. Type and duration of side effects were similar to that reported by the general population in Phase 3 testing trials of the mRNA vaccines. Clinical Trial Registration NCT04872738 posted May 4, 2021.

Indexed as

Breast NeoplasmsCOVID-19Drug-Related Side Effects and Adverse ReactionsLymphedemaCOVID-19 VaccinesFemaleHumansLymph Node ExcisionVaccinationCOVID-19 VaccinesBreast cancerCOVID-19LymphedemaLymphoedemaVaccines

Identifiers

PMID37031282
PMCPMC10098240
OpenAlexW4362722825

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.