Trial reportCritical care (London, England)2023
The increase in cardiac output induced by a decrease in positive end-expiratory pressure reliably detects volume responsiveness: the PEEP-test study.
Trial report in Critical care (London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Use of Heart-lung Interaction Parameters to Predict Haemodynamic Tolerance to the Open Lung Approach With Individualised PEEP During Invasive Mechanical Ventilation in the Operating Room
Effect of Positive End-Expiratory Pressure on Tricuspid Regurgitant Jet Velocity in Pediatric Patients on Invasive Mechanical Ventilation
Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- Heliox ventilation promotes pulmonary circulation and cardiac function in elderly hypertensive patients: a randomized controlled trial.Medical gas research · 2026Trial
- Effects of individualized PEEP titration on intraoperative cardiac output in thoracoscopic lung surgery: a prospective randomized trial.Scientific reports · 2026Trial
- Article
- Respiratory variation in carotid artery blood flow peak velocity combined with tidal volume challenge in predicting fluid responsiveness of lung-protective ventilation patients: a feasibility study.Journal of clinical monitoring and computing · 2026Article
- Invasive ventilation and association with outcomes in heart failure-related cardiogenic shock.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Fluid management methods for severely burned patients: a narrative review.Journal of clinical monitoring and computing · 2026Review
- Current Insights into Clinical, Molecular, and Therapeutic Approaches to Acute Respiratory Distress Syndrome.Medical sciences (Basel, Switzerland) · 2026Review
- Early time-weighted average PEEP and mortality in sepsis-associated myocardial injury requiring invasive mechanical ventilation: a retrospective cohort study with external validation.Frontiers in cellular and infection microbiology · 2026Article
- Applied physiology at the bedside: using invasive blood pressure as a true monitoring tool.Annals of intensive care · 2025Review
- Pathophysiology and clinical applications of PEEP in acute brain injury.Intensive care medicine · 2025Review
- Non-Invasive Hemodynamic Monitoring in Critically Ill Patients: A Guide for Emergency Physicians.Journal of clinical medicine · 2025Review
- Comparative assessment of hemodynamic changes and outcomes in ventilator weaning.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2025Article
- Positive End-Expiratory Pressure Titration Based on Lung Mechanics May Improve Pulse Pressure Variation Interpretation in Acute Respiratory Distress Syndrome Patients.Critical care explorations · 2025Article
- Acute Respiratory Distress Syndrome and Fluid Management: Finding the Perfect Balance.Journal of clinical medicine · 2025Review
- Why do we use transpulmonary thermodilution and pulmonary artery catheter in severe shock patients?Annals of intensive care · 2025Article
- Using the ventilator to predict fluid responsiveness.Intensive care medicine · 2025Article
- Navigating Heart-Lung Interactions in Mechanical Ventilation: Pathophysiology, Diagnosis, and Advanced Management Strategies in Acute Respiratory Distress Syndrome and Beyond.Journal of clinical medicine · 2024Article
- Testing preload responsiveness by the tidal volume challenge assessed by the photoplethysmographic perfusion index.Critical care (London, England) · 2024Article
- Heart-Lungs interactions: the basics and clinical implications.Annals of intensive care · 2024Review
- Recent advances in cardiorespiratory monitoring in acute respiratory distress syndrome patients.Journal of intensive care · 2024Review
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn patients on mechanical ventilation, positive end-expiratory pressure (PEEP) can decrease cardiac output through a decrease in cardiac preload and/or an increase in right ventricular afterload. Increase in central blood volume by fluid administration or passive leg raising (PLR) may reverse these phenomena through an increase in cardiac preload and/or a reopening of closed lung microvessels. We hypothesized that a transient decrease in PEEP (PEEP-test) may be used as a test to detect volume responsiveness.
methodsMechanically ventilated patients with PEEP ≥ 10 cmH
resultsWe enrolled 64 patients among whom 31 were volume responsive. The median increase in CI during PLR was 14% (11-16%). The median PEEP at baseline was 12 (10-15) cmH
conclusionsA CI increase > 8.6% during a PEEP-test, which consists in reducing PEEP to 5 cmH
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.