Evidence map›Paper›PMID 37031164›Full record

Observational studyRespiratory research2023

Chronic Airways Assessment Test: psychometric properties in patients with asthma and/or COPD.

Erin L Tomaszewski, Mark J Atkinson, Christer Janson, Niklas Karlsson, Barry Make, David Price, Helen K Reddel, Claus F Vogelmeier, Hana Müllerová, Paul W Jones and 2 more

3 registry-linked trialsOpen access · goldAbstract readComparative StudyObservational Study
In one paragraph

Observational study in Respiratory research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02760329 completednot on this map

A NOVEL Observational longiTudinal studY on Patients With Asthma and/or COPD to Describe Patient Characteristics, Treatment Patterns and the Burden of Illness Over Time and to Identify Phenotypes and Endotypes.

TypeobservationalSponsorAstraZenecaRan2016 to 2023Enrolled12,255ConditionsAsthma, COPD, Chronic Obstructive Pulmonary DiseaseArmsBlood draw, Urine, Lung function measurements, Fractional Exhaled Nitric Oxide (FENO)
NCT06459011 recruitingnot on this mapstarted 2024, after this paper: background citation

TAKINGCARE - TAcKlING the Needs of Carers of People With Chronic respirAtoRy disEases

TypeobservationalSponsorAveiro UniversityRan2024 to 2028Enrolled250ConditionsChronic Respiratory Disease
NCT07088926 phase2recruitingnot on this mapstarted 2025, after this paper: background citation

A Phase IIb Randomized, Double-blind, Placebo-controlled, Parallel, Multidose Study to Evaluate the Efficacy, Safety, and PK of AZD0292 in Participants 12 Years of Age and Older With Bronchiectasis and Chronic Pseudomonas Aeruginosa Colonization

TypeinterventionalSponsorAstraZenecaRan2025 to 2028Enrolled435ConditionsBronchiectasis With Pseudomonas Aeruginosa ColonizationArmsAZD0292, Placebo
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

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  9. Design of the SPIROMICS Study of Early COPD Progression: SOURCE Study.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2024
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  11. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 11 institutions in 7 countries.

Erin L TomaszewskiBioPharmaceuticals Medical, AstraZeneca, 1 Medimmune Way, Gaithersburg, MD, USA. Erin.tomaszewski@astrazeneca.com.
Mark J AtkinsonEvidera, Bethesda, MD, USA.
Christer JansonDepartment of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden.
Niklas KarlssonBioPharmaceuticals Medical, AstraZeneca, Gothenburg, Sweden.
Barry MakeNational Jewish Health and University of Colorado Denver, Denver, CO, USA.
David PriceObservational and Pragmatic Research Institute, Singapore, Singapore.
Helen K ReddelThe Woolcock Institute of Medical Research, The University of Sydney, Sydney, NSW, Australia.
Claus F VogelmeierDepartment of Medicine, Pulmonary and Critical Care Medicine, German Center for Lung Research (DZL), University of Marburg, Marburg, Germany.
Hana MüllerováBioPharmaceuticals Medical, AstraZeneca, Cambridge, UK.
Paul W JonesGlobal Respiratory Franchise, GlaxoSmithKline, Brentford, Middlesex, UK.
NOVELTY Scientific Community
NOVELTY study investigators
University of Aberdeen · GBUppsala University · SEThe University of Sydney · AUAstraZeneca (United Kingdom) · GBNational Jewish Health · USAstraZeneca (United States) · USGlaxoSmithKline (United Kingdom) · GBAstraZeneca (France) · FRAstraZeneca (Sweden) · SEGerman Center for Lung Research · DEIthaka Harbors · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNo short patient-reported outcome (PRO) instruments assess overall health status across different obstructive lung diseases. Thus, the wording of the introduction to the Chronic Obstructive Pulmonary Disease (COPD) Assessment Test (CAT) was modified to permit use in asthma and/or COPD. This tool is called the Chronic Airways Assessment Test (CAAT).

methodsThe psychometric properties of the CAAT were evaluated using baseline data from the NOVELTY study (NCT02760329) in patients with physician-assigned asthma, asthma + COPD or COPD. Analyses included exploratory/confirmatory factor analyses, differential item functioning and analysis of construct validity. Responses to the CAAT and CAT were compared in patients with asthma + COPD and those with COPD.

resultsCAAT items were internally consistent (Cronbach's alpha: > 0.7) within each diagnostic group (n = 510). Models for structural and measurement invariance were strong. Tests of differential item functioning showed small differences between asthma and COPD in individual items, but these were not consistent in direction and had minimal overall impact on the total score. The CAAT and CAT were highly consistent when assessed in all NOVELTY patients who completed both (N = 277, Pearson's correlation coefficient: 0.90). Like the CAT itself, CAAT scores correlated moderately (0.4-0.7) to strongly (> 0.7) with other PRO measures and weakly (< 0.4) with spirometry measures.

conclusionsCAAT scores appear to reflect the same health impairment across asthma and COPD, making the CAAT an appropriate PRO instrument for patients with asthma and/or COPD. Its brevity makes it suitable for use in clinical studies and routine clinical practice.

trial registrationNCT02760329.

Indexed as

AsthmaPatient Reported Outcome MeasuresPulmonary Disease, Chronic ObstructiveHumansPsychometricsQuality of LifeReproducibility of ResultsSurveys and QuestionnairesAsthmaChronic Airways Assessment TestCOPDCOPD Assessment TestPatient-reportedPsychometrics

Identifiers

PMID37031164
PMCPMC10082977
OpenAlexW4362717750

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.