Evidence map›Paper›PMID 37031075›Full record

ArticleClinical oncology (Royal College of Radiologists (Great Britain))2023

Decision Regret among Patients with Early-stage Lung Cancer Undergoing Radiation Therapy or Surgical Resection.

D R Sullivan, J P Wisnivesky, S M Nugent, K Stone, M K Farris, J A Kern, S Swanson, C B Smith, K Rosenzweig, C G Slatore

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical oncology (Royal College of Radiologists (Great Britain)), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04574518 (Teachable Moment to Opt-out of Tobacco), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04574518 naactive not recruitingnot on this map

Teachable Moment to Opt-out of Tobacco (TeaM OUT): A Stepped Wedge Cluster Randomized Intervention

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2022 to 2026Enrolled223ConditionsSolitary Pulmonary Nodule, Multiple Pulmonary Nodules, Tobacco UseArmsTeaM OUT Intervention, Enhanced Usual Care
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Decision regret in patients with rectal cancer undergoing multimodal therapy.Clinical and translational radiation oncology · 2026
    Article
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

D R SullivanDivision of Pulmonary & Critical Care Medicine (PCCM), OHSU, Portland, OR, USA; Center to Improve Veteran Involvement in Care (CIVIC), VA-Portland Health Care System (VAPORHCS), Portland, OR, USA; Knight Cancer Institute, OHSU, Portland, OR, USA. Electronic address: sullivad@ohsu.edu.
J P WisniveskyDivision of General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA; Division of PCCM Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
S M NugentCenter to Improve Veteran Involvement in Care (CIVIC), VA-Portland Health Care System (VAPORHCS), Portland, OR, USA; Knight Cancer Institute, OHSU, Portland, OR, USA.
K StoneDivision of General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA; Division of PCCM Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
M K FarrisDepartment of Radiation Oncology, Wake Forest Baptist Atrium Health, Winston-Salem, NC, USA.
J A KernDivision of Oncology, National Jewish Health, Denver, CO, USA.
S SwansonDepartment of Surgery, Brigham and Women's Hospital, Boston, MA, USA; Division of Surgical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
C B SmithDivision of Hematology and Medical Oncology, Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
K RosenzweigDepartment of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
C G SlatoreDivision of Pulmonary & Critical Care Medicine (PCCM), OHSU, Portland, OR, USA; Center to Improve Veteran Involvement in Care (CIVIC), VA-Portland Health Care System (VAPORHCS), Portland, OR, USA; Knight Cancer Institute, OHSU, Portland, OR, USA; Section of PCCM, VAPORHCS, Portland, OR, USA.
Icahn School of Medicine at Mount Sinai · USUniversity of Portland · USAtrium Health Wake Forest Baptist · USDana-Farber Cancer Institute · USNational Jewish Health · USOHSU Knight Cancer Institute

Funding

Comparative Effectiveness of Limited Resection vs. Stereotactic Body Radiation Therapy for Early Stage Lung CancerR01CA203193 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI WISNIVESKY, JUAN P · 2016 to 2020
$3.2M
NCI NIH HHS R01 CA203193
6 · The paper itself

Abstract

aimsClinical equipoise exists regarding early-stage lung cancer treatment among patients as trials comparing stereotactic body radiation therapy (SBRT) and surgical resection are unavailable. Given the potential differences in treatment effectiveness and side-effects, we sought to determine the associations between treatment type, decision regret and depression. MATERIALS AND

methodsA multicentre, prospective study of patients with stage IA-IIA non-small cell lung cancer (NSCLC) with planned treatment with SBRT or surgical resection was conducted. Decision regret and depression were measured using the Decision Regret Scale (DRS) and Patient Health Questionnaire-4 (PHQ-4) at 3, 6 and 12 months post-treatment, respectively. Mixed linear regression modelling examined associations between treatment and decision regret adjusting for patient sociodemographics.

resultsAmong 211 study participants with early-stage lung cancer, 128 (61%) patients received SBRT and 83 (39%) received surgical resection. The mean age was 73 years (standard deviation = 8); 57% were female; 79% were White non-Hispanic. In the entire cohort at 3 months post-treatment, 72 (34%) and 57 (27%) patients had mild and severe decision regret, respectively. Among patients who received SBRT or surgery, 71% and 46% of patients experienced at least mild decision regret at 3 months, respectively. DRS scores increased at 6 months and decreased slightly at 12 months of follow-up in both groups. Higher DRS scores were associated with SBRT treatment (adjusted mean difference = 4.18, 95% confidence interval 0.82 to 7.54) and depression (adjusted mean difference = 3.49, 95% confidence interval 0.52 to 6.47). Neither patient satisfaction with their provider nor decision-making role concordance was associated with DRS scores.

conclusionsMost early-stage lung cancer patients experienced at least mild decision regret, which was associated with SBRT treatment and depression symptoms. Findings suggest patients with early-stage lung cancer may not be receiving optimal treatment decision-making support. Therefore, opportunities for improved patient-clinician communication probably exist.

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsRadiosurgeryAgedEmotionsFemaleHumansMaleNeoplasm StagingProspective StudiesTreatment OutcomeDecision makingdepressionlung neoplasmsquality of liferadiationthoracic surgery

Identifiers

PMID37031075
PMCPMC10241560
OpenAlexW4361285532

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.