ArticleMolecular metabolism2023
Fibroblast growth factor-21 is required for weight loss induced by the glucagon-like peptide-1 receptor agonist liraglutide in male mice fed high carbohydrate diets.
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Article in Molecular metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 40 citations in OpenAlex.
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Authors and funding
19 authors at 7 institutions in 2 countries.
Thao D V LeDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 2215 Garland Avenue, Nashville, TN 37232, USA. Electronic address: thao.d.le@vanderbilt.edu.
Payam FathiDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 2215 Garland Avenue, Nashville, TN 37232, USA. Electronic address: payam.fathi@vanderbilt.edu.
Amanda B WattersDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 2215 Garland Avenue, Nashville, TN 37232, USA. Electronic address: awatters@tulane.edu.
Blair J EllisDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 2215 Garland Avenue, Nashville, TN 37232, USA.
Gai-Linn K BesingDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 2215 Garland Avenue, Nashville, TN 37232, USA. Electronic address: gai-linn.besing.1@vanderbilt.edu.
Nadejda Bozadjieva-KramerDepartment of Surgery, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA; Veterans Affairs Ann Arbor Healthcare System, Research Service, 2215 Fuller Road, Ann Arbor, MI 48105, USA. Electronic address: nibozad@med.umich.edu.
Misty B PerezDepartment of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, 375 Newton Road, Iowa City, IA 52242, USA. Electronic address: misty-perez@uiowa.edu.
Andrew I SullivanDepartment of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, 375 Newton Road, Iowa City, IA 52242, USA. Electronic address: andrew-sullivan-1@uiowa.edu.
Jesse P RoseDepartment of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, 375 Newton Road, Iowa City, IA 52242, USA. Electronic address: jesse-rose@uiowa.edu.
Laurie L BaggioLunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Department of Medicine, University of Toronto, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada. Electronic address: baggio@lunenfeld.ca.
Jacqueline KoehlerLunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Department of Medicine, University of Toronto, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada.
Jennifer L BrownDuke Molecular Physiology Institute, Duke University, 300 N. Duke Street, Durham, NC 27701, USA.
Michelle B BalesDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 2215 Garland Avenue, Nashville, TN 37232, USA. Electronic address: bales@psy.fsu.edu.
Kaitlyn G NwabaDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 2215 Garland Avenue, Nashville, TN 37232, USA.
Jonathan E CampbellDuke Molecular Physiology Institute, Duke University, 300 N. Duke Street, Durham, NC 27701, USA. Electronic address: jonathan.campbell@duke.edu.
Daniel J DruckerLunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Department of Medicine, University of Toronto, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada. Electronic address: drucker@lunenfeld.ca.
Matthew J PotthoffDepartment of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, 375 Newton Road, Iowa City, IA 52242, USA. Electronic address: matthew-potthoff@uiowa.edu.
Randy J SeeleyDepartment of Surgery, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address: seeleyrj@med.umich.edu.
Julio E AyalaDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 2215 Garland Avenue, Nashville, TN 37232, USA; Vanderbilt Mouse Metabolic Phenotyping Center, Vanderbilt University School of Medicine, 2215 Garland Avenue, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University School of Medicine, 2215 Garland Avenue, Nashville, TN 37232, USA. Electronic address: julio.e.ayala@vanderbilt.edu.
Vanderbilt University · USUniversity of Iowa · USDuke University · USMount Sinai Hospital · CALunenfeld-Tanenbaum Research Institute · CAUniversity of Michigan–Ann Arbor · USVA Ann Arbor Healthcare System · US
Funding
Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Amy Leanne Ryan · 1998 to 2026
$30.5MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3MPilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Kanakadurga Singer · 2010 to 2026
$20.3MMULTIDISCIPLINARY TRAINING IN MOLECULAR ENDOCRINOLOGYT32DK007563 · NIDDK · VANDERBILT UNIVERSITY · PI Richard M O'Brien · 1988 to 2026
$15.9MENGINEERED GLUCOSE METABOLISM IN INSULIN-SECRETING CELLSR01DK046492 · NIDDK · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI NEWGARD, CHRISTOPHER B · 1993 to 2025
$7.8MVanderbilt Mouse Metabolic Phenotyping CenterU2CDK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2016 to 2021
$6.3MRegulation of Metabolism by FGF21R01DK106104 · NIDDK · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Matthew Joseph Potthoff · 2015 to 2026
$6.2MNovel metabolic actions of GIPR01DK125353 · NIDDK · DUKE UNIVERSITY · PI CAMPBELL, JONATHAN E, D'ALESSIO, DAVID A. · 2020 to 2024
$2.1MMechanisms of insulin secretion mediated by alpha cellsR01DK123075 · NIDDK · DUKE UNIVERSITY · PI CAMPBELL, JONATHAN E · 2019 to 2023
$1.9MPromethion Core SystemS10OD028455 · OD · VANDERBILT UNIVERSITY · PI AYALA, JULIO E · 2020 to 2020
$590kPromethion Mouse Multiplexed Metabolic SystemS10OD021680 · OD · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI AYALA, JULIO E · 2016 to 2016
$320kThe role of intestinal-derived FGF15/19 during obesity and rapid weight lossIK2BX005715 · VA · VETERANS HEALTH ADMINISTRATION · PI KRAMER, NADEJDA BOZADJIEVA · 2022 to 2025
–BLRD VA IK2 BX005715NIDDK NIH HHS P30 DK054759NIDDK NIH HHS P30 DK089503NIDDK NIH HHS R01 DK046492NIDDK NIH HHS R01 DK106104NIDDK NIH HHS R01 DK123075NIDDK NIH HHS R01 DK125353NIDDK NIH HHS T32 DK007563NIDDK NIH HHS U2C DK059637NIGMS NIH HHS T32 GM007347NIH HHS S10 OD021680NIH HHS S10 OD028455
Abstract
objectiveGlucagon-like peptide-1 receptor (GLP-1R) agonists (GLP-1RA) and fibroblast growth factor-21 (FGF21) confer similar metabolic benefits. GLP-1RA induce FGF21, leading us to investigate mechanisms engaged by the GLP-1RA liraglutide to increase FGF21 levels and the metabolic relevance of liraglutide-induced FGF21.
methodsCirculating FGF21 levels were measured in fasted male C57BL/6J, neuronal GLP-1R knockout, β-cell GLP-1R knockout, and liver peroxisome proliferator-activated receptor alpha knockout mice treated acutely with liraglutide. To test the metabolic relevance of liver FGF21 in response to liraglutide, chow-fed control and liver Fgf21 knockout (Liv
resultsLiraglutide increases FGF21 levels independently of decreased food intake via neuronal GLP-1R activation. Lack of liver Fgf21 expression confers resistance to liraglutide-induced weight loss due to attenuated reduction of food intake in chow-fed mice. Liraglutide-induced weight loss was impaired in Liv
conclusionsOur findings support a novel role for a GLP-1R-FGF21 axis in regulating body weight in a dietary carbohydrate-dependent manner.
Indexed as
Glucagon-Like Peptide-1 ReceptorLiraglutideAnimalsCarbohydratesDiet, High-FatFibroblast Growth FactorsMaleMiceMice, Inbred C57BLWeight LossCarbohydratesfibroblast growth factor 21Fibroblast Growth FactorsGlucagon-Like Peptide-1 ReceptorLiraglutideCarbohydrateFibroblast growth factor-21Food intakeGlucagon-like peptide-1 receptor agonistsLiraglutideWeight loss
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