Evidence map›Paper›PMID 37030416›Full record

ArticleThe Journal of steroid biochemistry and molecular biology2023

Vitamin K2 enhances the tumor suppressive effects of 1,25(OH)

Carmen J Narvaez, Min Ji Bak, Natalia Salman, JoEllen Welsh

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of steroid biochemistry and molecular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Carmen J NarvaezCancer Research Center, University at Albany, Rensselaer, NY 12144, United States.
Min Ji BakCancer Research Center, University at Albany, Rensselaer, NY 12144, United States.
Natalia SalmanCancer Research Center, University at Albany, Rensselaer, NY 12144, United States.
JoEllen WelshCancer Research Center, University at Albany, Rensselaer, NY 12144, United States. Electronic address: jwelsh@albany.edu.
University at Albany, State University of New York · US

Funding

Vitamin D and HA Signaling in TNBCR01CA194500 · NCI · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI WELSH, JOELLEN · 2015 to 2019
$2.2M
Vitamin K: Body Pools and Function in Breast CancerR01CA258231 · NCI · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI WELSH, JOELLEN · 2021 to 2025
$2.0M
NCI NIH HHS R01 CA194500NCI NIH HHS R01 CA258231
6 · The paper itself

Abstract

K vitamins are well known as essential cofactors for hepatic γ-carboxylation of coagulation factors, but their potential role in chronic diseases including cancer is understudied. K2, the most abundant form of vitamin K in tissues, exerts anti-cancer effects via diverse mechanisms which are not completely understood. Our studies were prompted by previous work demonstrating that the K2 precursor menadione synergized with 1,25 dihydroxyvitamin D3 (1,25(OH)

Indexed as

CalcitriolTriple Negative Breast NeoplasmsHumansReceptors, CalcitriolTumor Cells, CulturedVitamin KVitamin K 2VitaminsCalcitriolReceptors, CalcitriolVitamin KVitamin K 2VitaminsBreast cancerMenaquinone-4TNBCVitamin DVitamin K2

Identifiers

PMID37030416
PMCPMC10752295
OpenAlexW4362673273

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.