Evidence map›Paper›PMID 37030330›Full record

ArticleJournal of affective disorders2023

Robust caregiver-youth discrepancies in irritability ratings on the affective reactivity index: An investigation of its origins.

Ajitha Mallidi, Tatiana Meza-Cervera, Katharina Kircanski, Argyris Stringaris, Melissa A Brotman, Daniel S Pine, Ellen Leibenluft, Julia O Linke

Open access · hybridAbstract read
In one paragraph

Article in Journal of affective disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

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  10. Concurrent and longitudinal neurostructural correlates of irritability in children.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
  11. Sleepless nights, sour moods: daily sleep-irritability links in a pediatric clinical sample.Journal of child psychology and psychiatry, and allied disciplines · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Ajitha MallidiEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States of America.
Tatiana Meza-CerveraEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States of America.
Katharina KircanskiEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States of America.
Argyris StringarisDivisions of Psychiatry and Psychology and Language Sciences, University College London, United Kingdom.
Melissa A BrotmanEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States of America.
Daniel S PineEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States of America.
Ellen LeibenluftEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States of America.
Julia O LinkeEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States of America. Electronic address: dr.julia.linke@gmail.com.
National Institute of Mental Health · USNational Institutes of Health · USUniversity College London · GB

Funding

The Pathophysiology and Treatment Of Children With Severe Mood DysregulationZIAMH002786 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI LEIBENLUFT, ELLEN · 2009 to 2023
$34.0M
Fmri Studies Of Risk For Mood And Anxiety Disorders In ChildrenZIAMH002782 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PINE, DANIEL · 2009 to 2025
$28.3M
Unit on Neuroscience and Novel TherapeuticsZIAMH002969 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI BROTMAN, MELISSA · 2019 to 2025
$13.8M
The Phenomenology And Neurophysiology Of Juvenile Bipolar DisorderZIAMH002778 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI LEIBENLUFT, ELLEN · 2009 to 2017
$10.8M
Intramural NIH HHS ZIA MH002778Intramural NIH HHS ZIA MH002782Intramural NIH HHS ZIA MH002786
6 · The paper itself

Abstract

objectiveThe Affective Reactivity Index (ARI) is widely used to assess young people's irritability symptoms, but youth and caregivers often diverge in their assessments. Such informant discrepancy might be rooted in poor psychometric properties, the differential conceptualization of irritability across informants, or reflect sociodemographic and clinical characteristics. We use an out-of-sample replication approach and leverage longitudinal data, available for a subset of the participants, to test these hypotheses.

methodAcross two independent samples (N

resultsDespite good internal consistency and 6-week-retest-reliability of parent (Cohort-1: α = 0.92, ICC = 0.85; Cohort-2: α = 0.93) and youth forms (Cohort-1: α = 0.88, ICC = 0.78; Cohort-2: α = 0.82), we confirm substantial informant discrepancy in ARI ratings (3 points on a scale from 0 to 12), which is stable over six weeks (ICC = 0.53). Measurement invariance across informants was weak, indicating that parents and youth may interpret ARI items differently. Irritability severity and diagnostic status predicted informant-discrepancy, albeit in opposing directions: higher severity was linked to relative, higher irritability-ratings by youth (Cohort-1: β = -0.06, p < .001; Cohort-2: β = -0.06, p < .001), while diagnoses of Disruptive Mood Dysregulation Disorder (Cohort-1: β = 0.44, p < .001; Cohort-2: β = 0.84, p < .001) and Oppositional Defiant Disorder (Cohort-1: β = 0.41, p < .001; Cohort-2: β = 0.42, p < .001) predicted relative higher irritability-ratings by caregivers. In both datasets, a bifactor model parsing informant-specific from shared irritability-related variance fit the data well (CFI = 0.99, RMSEA = 0.05; N

conclusionParent and youth ARI reports and their discrepancy are reliable and reflect different interpretations of the scale items; hence they should not be averaged. This finding also suggests that irritability is not a unitary construct. Future work should investigate and model how different aspects of irritability might differ in their impact on the responses of specific informants.

Indexed as

CaregiversIrritable MoodAdolescentAttention Deficit and Disruptive Behavior DisordersHumansMood DisordersReproducibility of ResultsAffective reactivity indexBifactor modelInformant discrepancyIrritabilityMeasurement invarianceRetest-reliability

Identifiers

PMID37030330
PMCPMC10170868
OpenAlexW4362658828

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.